Modularity: Genes, Development, and Evolution

Modularity has emerged as a central concept for evolutionary biology, thereby providing the field with a theory of organismal structure and variation. This theory has reframed long-standing questions and serves as a unified conceptual framework for genetics, developmental biology, and multivariate e...

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Bibliographic Details
Published in:Annual review of ecology, evolution, and systematics evolution, and systematics, 2016-01, Vol.47 (1), p.463-486
Main Authors: Melo, Diogo, Porto, Arthur, Cheverud, James M, Marroig, Gabriel
Format: Article
Language:English
Subjects:
adaptive landscape
Evolution
G-matrix
Genes
Genetics
genotype-phenotype map
Macroevolution
Modularity
morphological integration
Research programs
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Summary:Modularity has emerged as a central concept for evolutionary biology, thereby providing the field with a theory of organismal structure and variation. This theory has reframed long-standing questions and serves as a unified conceptual framework for genetics, developmental biology, and multivariate evolution. Research programs in systems biology and quantitative genetics are bridging the gap between these fields. Although this synthesis is ongoing, some major themes have emerged, and empirical evidence for modularity has become abundant. In this review, we look at modularity from a historical perspective, highlighting its meaning at different levels of biological organization and the different methods that can be used to detect it. We then explore the relationship between quantitative genetic approaches to modularity and developmental genetic studies. We conclude by investigating the dynamic relationship between modularity and the adaptive landscape and how this relationship potentially shapes evolution and can help bridge the gap between micro- and macroevolution.
ISSN:1543-592X
1545-2069
DOI:10.1146/annurev-ecolsys-121415-032409