Synthesis of 2,3-Diarylisoindolin-1-one by Copper-Catalyzed Cascade Annulation of 2‑Formylbenzonitriles, Arenes, and Diaryliodonium Salts

A three-component cascade cyclization was developed to synthesize 2,3-diarylisoindolin-1-one by using 2-formylbenzonitrile, arenes, and diaryliodonium salts. The process underwent copper-catalyzed tandem C–N/C–C bond formation, producing isoindolin-1-one derivatives in good to excellent yields.

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Published in:Journal of organic chemistry 2017-10, Vol.82 (20), p.11084-11090
Main Authors: Liu, Li, Bai, Shu-Hua, Li, Yang, Wang, Li-Xun, Hu, Yang, Sung, Hui-Ling, Li, Jian
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Language:English
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cited_by cdi_FETCH-LOGICAL-a333t-138446386e95ca622b15468d46b9b57d3e51e668d5438dcc5328c4a40c2dff233
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container_issue 20
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container_title Journal of organic chemistry
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creator Liu, Li
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description A three-component cascade cyclization was developed to synthesize 2,3-diarylisoindolin-1-one by using 2-formylbenzonitrile, arenes, and diaryliodonium salts. The process underwent copper-catalyzed tandem C–N/C–C bond formation, producing isoindolin-1-one derivatives in good to excellent yields.
doi_str_mv 10.1021/acs.joc.7b02035
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title Synthesis of 2,3-Diarylisoindolin-1-one by Copper-Catalyzed Cascade Annulation of 2‑Formylbenzonitriles, Arenes, and Diaryliodonium Salts
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