M2 polarization of monocytes in ankylosing spondylitis and relationship with inflammation and structural damage

The aim of this study was to evaluate the polarization of peripheral blood monocytes in the patients with ankylosing spondylitis (AS) and to determine the correlations between monocyte polarization and inflammation and structural damage. A total of 120 AS patients, 50 rheumatoid arthritis (RA) patie...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2017-12, Vol.125 (12), p.1070-1075
Main Authors: Zhao, Jinzhu, Yuan, Wei, Tao, Chunsheng, Sun, Peifeng, Yang, Zaixing, Xu, Weidong
Format: Article
Language:English
Subjects:
Ankylosing spondylitis
Arthritis
Biomarkers
CD163 antigen
CX3CR1 protein
Cytometry
Damage assessment
Data processing
Demographics
disease activity
Flow cytometry
Inflammation
monocyte polarization
Monocytes
Patients
Peripheral blood
Polarization
Rheumatoid arthritis
Spine
Spondylitis
Structural damage
Tumor necrosis factor
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container_title APMIS : acta pathologica, microbiologica et immunologica Scandinavica
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creator Zhao, Jinzhu
Yuan, Wei
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Sun, Peifeng
Yang, Zaixing
Xu, Weidong
description The aim of this study was to evaluate the polarization of peripheral blood monocytes in the patients with ankylosing spondylitis (AS) and to determine the correlations between monocyte polarization and inflammation and structural damage. A total of 120 AS patients, 50 rheumatoid arthritis (RA) patients and 100 healthy controls were enrolled in the study. M1 (CD68+CD192+) and M2 (CX3CR1+CD163+) monocytes were characterized by flow cytometry. Demographic, clinical, radiographic and laboratory data were collected and analyzed. A large increase in M2 (CX3CR1+CD163+) monocytes was observed in AS, and M2/M1 ratio was 7.18 ± 6.12, 2.54 ± 3.14 and 35.61 ± 20.04 in control, RA and AS, respectively. The M2/M1 ratio correlated with modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) (r = 0.565; p 
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A total of 120 AS patients, 50 rheumatoid arthritis (RA) patients and 100 healthy controls were enrolled in the study. M1 (CD68+CD192+) and M2 (CX3CR1+CD163+) monocytes were characterized by flow cytometry. Demographic, clinical, radiographic and laboratory data were collected and analyzed. A large increase in M2 (CX3CR1+CD163+) monocytes was observed in AS, and M2/M1 ratio was 7.18 ± 6.12, 2.54 ± 3.14 and 35.61 ± 20.04 in control, RA and AS, respectively. The M2/M1 ratio correlated with modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) (r = 0.565; p &lt; 0.001), ESR (r = −0.321; p &lt; 0.001, CRP (r = −0.265; p &lt; 0.001) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (r = −0.201; p = 0.028). Anti‐TNF‐α therapy induced a significant reduction in the percentage of M1 monocyte, ESR, CRP and BASDAI in AS patients. 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subjects Ankylosing spondylitis
Arthritis
Biomarkers
CD163 antigen
CX3CR1 protein
Cytometry
Damage assessment
Data processing
Demographics
disease activity
Flow cytometry
Inflammation
monocyte polarization
Monocytes
Patients
Peripheral blood
Polarization
Rheumatoid arthritis
Spine
Spondylitis
Structural damage
Tumor necrosis factor
title M2 polarization of monocytes in ankylosing spondylitis and relationship with inflammation and structural damage
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