Prognostic factors in head and neck mucoepidermoid carcinoma: experience at a single institution based on 64 consecutive patients over a 28-year period

Mucoepidermoid carcinoma (MEC) is the most common malignancy of the salivary glands. The clinical behaviour of MEC is largely unpredictable, ranging from indolent tumour growth to highly aggressive metastatic spread. The objective of this study was to determine the clinicopathological predictors of...

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Bibliographic Details
Published in:International journal of oral and maxillofacial surgery 2018-03, Vol.47 (3), p.283-288
Main Authors: Granic, M., Suton, P., Mueller, D., Cvrljevic, I., Luksic, I.
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Mucoepidermoid - pathology
Carcinoma, Mucoepidermoid - surgery
Dentistry
Disease-Free Survival
Female
head and neck
Humans
Lymphatic Metastasis
Male
Middle Aged
mucoepidermoid carcinoma
Neoplasm Grading
Neoplasm Recurrence, Local
Neoplasm Staging
Prognosis
recurrence
Salivary Gland Neoplasms - pathology
Salivary Gland Neoplasms - surgery
salivary gland tumours
survival
Treatment Outcome
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Summary:Mucoepidermoid carcinoma (MEC) is the most common malignancy of the salivary glands. The clinical behaviour of MEC is largely unpredictable, ranging from indolent tumour growth to highly aggressive metastatic spread. The objective of this study was to determine the clinicopathological predictors of recurrence and survival in patients with head and neck MEC. The medical records of 64 patients who underwent surgical treatment for head and neck MEC between 1982 and 2010 were reviewed. The main outcome measures were disease-free survival (DFS) and overall survival (OS). Clinicopathological parameters evaluated were age, sex, anatomical subsite, histological grade, tumour stage, tumour size, adjuvant therapy, and nodal and margin status. For the entire cohort, the 5-year DFS was 82.8% and the 5-year OS was 67.2%. Histological grade and tumour subsite were statistically significant predictors of OS. Furthermore, tumour stage and nodal status were statistically significant predictors with respect to OS. Advanced tumour stage, high histological grade, submandibular/sublingual localization, and positive nodal status were independent predictors of the prognosis in patients with head and neck MEC. Further studies into the molecular biology of MEC are needed in order to provide new therapeutic strategies for patients with locally aggressive and highly metastatic carcinomas.
ISSN:0901-5027
1399-0020
DOI:10.1016/j.ijom.2017.09.005