Dominant high expression of wild‐type HSP110 defines a poor prognostic subgroup of colorectal carcinomas with microsatellite instability: a whole‐section immunohistochemical analysis

The aim of this study is to establish heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability‐high (MSI‐H) by considering the intratumoral heterogeneity of HSP110 expression. We performed whole‐section immunohistochemistry (IHC) for w...

Full description

Saved in:
Bibliographic Details
Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2017-12, Vol.125 (12), p.1076-1083
Main Authors: Oh, Hyeon Jeong, Kim, Jung Ho, Lee, Tae Hun, Park, Hye Eun, Bae, Jeong Mo, Lee, Hye Seung, Kang, Gyeong Hoon
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Colorectal cancer
Colorectal carcinoma
Criteria
heat shock protein
Heat shock proteins
Immune checkpoint inhibitors
Immunohistochemistry
Immunotherapy
Medical prognosis
Microsatellite instability
mismatch repair
prognosis
Stability
Stability analysis
Tumor cells
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study is to establish heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability‐high (MSI‐H) by considering the intratumoral heterogeneity of HSP110 expression. We performed whole‐section immunohistochemistry (IHC) for wild‐type HSP110 (HSP110wt) in 164 MSI‐H CRCs. The intensity of the HSP110wt expression in tumor cells was semiquantitatively scored (0/1/2/3), and the HSP110wt expression status of each tumor was classified as low or high using the following four scoring criteria: H‐score, dominant intensity score, lowest intensity score, and highest intensity score. Among the four criteria, only the dominant intensity score‐based dichotomous classification of HSP110wt expression was significantly associated with a difference in disease‐free survival (log‐rank p = 0.035) in 164 MSI‐H CRCs. The HSP110wt‐low MSI‐H CRCs were significantly correlated with larger deletions in the HSP110 T17 mononucleotide repeat (≥4 bp; p 
ISSN:0903-4641
1600-0463
DOI:10.1111/apm.12770