Oncologic results and quality of life in patients with squamous cell carcinoma of hypopharynx after transoral laser microsurgery

Objective Transoral laser microsurgery (TLM) is an alternative method for organ preservation in squamous cell carcinoma of hypopharynx (HPSCC). The purpose of this study was to analyze the oncologic results and quality of life (QOL) in HPSCC patients after TLM. Methods Forty‐six patients who underwe...

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Published in:Lasers in surgery and medicine 2018-02, Vol.50 (2), p.117-124
Main Authors: Hung, Li‐Ting, Huang, Hsin‐I, Wang, Ling‐Wei, Yang, Muh‐Hwa, Chu, Pen‐Yuan
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Cervix
Female
function
Humans
Hypopharynx
Laser Therapy - instrumentation
Lasers
Lymph nodes
Lymphatic Metastasis
Male
Mastectomy
Metastases
Microsurgery
Microsurgery - instrumentation
Middle Aged
Neoplasm Recurrence, Local
oncologic result
outcome
Patients
Pharyngeal Neoplasms - pathology
Pharyngeal Neoplasms - surgery
Preservation
Quality of Life
Radiation therapy
Squamous cell carcinoma
Surgery
Survival Rate
Throat cancer
transoral laser microsurgery
Treatment Outcome
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Summary:Objective Transoral laser microsurgery (TLM) is an alternative method for organ preservation in squamous cell carcinoma of hypopharynx (HPSCC). The purpose of this study was to analyze the oncologic results and quality of life (QOL) in HPSCC patients after TLM. Methods Forty‐six patients who underwent TLM were included, 34 of them had QOL evaluations. The QOL analyses were measured with EORTC QLQ‐C‐30, QLQ‐H&N35, VHI‐30, and MDADI at least 6 months postoperatively. Results Most patients were male (96%) with a median age of 60 years. Four patients (9%) were at the T1 category, 24 (52%) at T2, 15 (33%) at T3, and 3 (7%) at T4. Twenty‐nine patients (63%) had cervical lymph node metastases and 26 (57%) received postoperative radiotherapy. With a median follow‐up of 61 months for all patients, 18 (39%) had tumor recurrence, including 4 local, 7 regional, and 7 distant. The 5‐year overall and disease‐specific survival (DSS) rates were 59% and 77%, respectively. The 5‐year laryngeal preservation rate was 89%. Most patients had satisfactory QOLs. Conclusion In early and selective moderately advanced HPSCC, TLM can achieve optimal oncologic results and satisfactory QOL. Lasers Surg. Med. 50:117–124, 2018.   © 2017 Wiley Periodicals, Inc.
ISSN:0196-8092
1096-9101
DOI:10.1002/lsm.22742