Acute Lung Injury in Response to Intratracheal Instillation of Lipopolysaccharide in an Animal Model of Emphysema Induced by Elastase

The response of lungs with emphysema to an acute lung injury (ALI) remains unclear. This study compared the lung response to intratracheal instillation of lipopolysaccharide (LPS) in rats with and without emphysema. Twenty-four Wistar rats were randomized to four groups: control group (C-G), ALI gro...

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Bibliographic Details
Published in:Inflammation 2018-02, Vol.41 (1), p.174-182
Main Authors: Rabelo, Maria Aparecida Esteves, Lucinda, Leda Marília Fonseca, Reboredo, Maycon Moura, da Fonseca, Lídia Maria Carneiro, Reis, Fernando Fonseca, Fazza, Thaís Fernanda, Brega, Danielle Ribeiro, de Paoli, Flavia, de Souza da Fonseca, Adenilson, Pinheiro, Bruno Valle
Format: Article
Language:English
Subjects:
Alveoli
Biomedical and Life Sciences
Biomedicine
Bronchus
Elastase
Emphysema
Gene expression
Immunology
Inflammation
Interleukin 6
Internal Medicine
Lipopolysaccharides
Lungs
Neutrophils
Original Article
Pathology
Pharmacology/Toxicology
Rheumatology
Rodents
Statistical analysis
Trachea
Tumor necrosis factor-α
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Summary:The response of lungs with emphysema to an acute lung injury (ALI) remains unclear. This study compared the lung response to intratracheal instillation of lipopolysaccharide (LPS) in rats with and without emphysema. Twenty-four Wistar rats were randomized to four groups: control group (C-G), ALI group (ALI-G), emphysema group (E-G), emphysema and ALI group (E-ALI-G). Euthanasia and the following analysis were performed 24 h after ALI induction: lung histology, bronchoalveolar lavage (BAL), mRNA expression of inflammatory mediators, and blood gas measures. The histological analysis showed that animals of ALI-G (0.55 ± 0.15) and E-ALI-G (0.69 ± 0.08) had a higher ALI score compared to C-G (0.12 ± 0.04) and E-G (0.16 ± 0.04) ( p  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-017-0675-5