12( S)-HPETE induces itch-associated scratchings in mice

The itch-associated responses evoked by intradermal injection of 12( S)-HPETE and leukotriene B 4 were compared in ICR-mice. 12( S)-HPETE and leukotriene B 4 (0.01–0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12( S)-HPETE) or...

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Bibliographic Details
Published in:European journal of pharmacology 2007-01, Vol.554 (1), p.30-33
Main Authors: Kim, Dae-Kwon, Kim, Hyung-June, Sung, Ki-Sa, Kim, Hyuk, Cho, Sun-A, Kim, Kwang-Mi, Lee, Chang-Hoon, Kim, Jung-Ju
Format: Article
Language:English
Subjects:
12( S)-HPETE
Animals
Biological and medical sciences
Capsaicin - pharmacology
Dose-Response Relationship, Drug
Intradermal injection 12-lipoxygenase
Itch
Leukotriene B 4
Leukotriene B4 - pharmacology
Leukotrienes - pharmacology
Male
Medical sciences
Mice
Mice, Inbred ICR
Naltrexone - pharmacology
Pharmacology. Drug treatments
Pruritus - chemically induced
Receptors, Leukotriene B4 - antagonists & inhibitors
Scratching
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Summary:The itch-associated responses evoked by intradermal injection of 12( S)-HPETE and leukotriene B 4 were compared in ICR-mice. 12( S)-HPETE and leukotriene B 4 (0.01–0.2 nmol/site) induced scratching of the injected site, respectively; the dose-responses were a peak at 0.05 nmol/site (12( S)-HPETE) or 0.03 nmol/site (leukotriene B 4). The scratching response by 12( S)-HPETE (0.05 nmol/site) started within 1 min, peaked in the first 10 min period, had almost subsided by 25 min whereas the effect of leukotriene B 4 peaked in the second 10 min. The effect of leukotriene B 4 is slightly stronger than that of 12( S)-HPETE in 40 min of count. The scratching induced by 12( S)-HPETE was inhibited by capsaicin, naltrexon, and LY255283. These results suggest the possibility that 12-lipoxygenase product can be added to a new member of an endogenous itch mediator in the skin.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2006.09.057