The association of profilin‐1 levels with survival in chronic kidney disease

Background Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and n...

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Published in:European journal of clinical investigation 2017-12, Vol.47 (12), p.n/a
Main Authors: Eroglu, Eray, Unal, Hilmi U., Guclu, Aydin, Kocyigit, Ismail, Karaman, Murat, Saglam, Mutlu, Gezer, Mustafa, Tas, Ahmet, Zararsiz, Gokmen, Eyileten, Tayfun, Aydin, İbrahim, Oguz, Yusuf, Gungor, Ozkan, Yilmaz, Mahmut I.
Format: Article
Language:English
Subjects:
Actin
cardiovascular events
chronic kidney disease
Cytoskeleton
endothelial dysfunction
Endothelium
Enzyme-linked immunosorbent assay
Kidney transplantation
Patients
Polymerization
Profilin
profilin‐1
Survival
Ultrasound
Vasodilation
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Summary:Background Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1‐5 CKD. Materials and methods Serum concentrations of profilin‐1 levels were determined by enzyme‐linked immunosorbent assay. Endothelium‐dependent vasodilatation (flow‐mediated dilatation [FMD]) and endothelium‐independent vasodilatation (nitroglycerine‐mediated dilatation [NMD]) of the brachial artery were assessed noninvasively, using high‐resolution ultrasound. Results Both fatal and nonfatal CVE were significantly higher in patients with high profilin‐1 levels. Kaplan‐Meier survival curves showed that patients with profilin‐1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin‐1 levels above the median value (log‐rank test, P 
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.12839