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The association of profilin‐1 levels with survival in chronic kidney disease
Background Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and n...
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| Published in: | European journal of clinical investigation 2017-12, Vol.47 (12), p.n/a |
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| Main Authors: | , , , , , , , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c3539-6629c7f82437d3d2cfa30f0ace9fc738184b432eff02751b03513d46e65077323 |
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| container_issue | 12 |
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| container_title | European journal of clinical investigation |
| container_volume | 47 |
| creator | Eroglu, Eray Unal, Hilmi U. Guclu, Aydin Kocyigit, Ismail Karaman, Murat Saglam, Mutlu Gezer, Mustafa Tas, Ahmet Zararsiz, Gokmen Eyileten, Tayfun Aydin, İbrahim Oguz, Yusuf Gungor, Ozkan Yilmaz, Mahmut I. |
| description | Background
Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1‐5 CKD.
Materials and methods
Serum concentrations of profilin‐1 levels were determined by enzyme‐linked immunosorbent assay. Endothelium‐dependent vasodilatation (flow‐mediated dilatation [FMD]) and endothelium‐independent vasodilatation (nitroglycerine‐mediated dilatation [NMD]) of the brachial artery were assessed noninvasively, using high‐resolution ultrasound.
Results
Both fatal and nonfatal CVE were significantly higher in patients with high profilin‐1 levels. Kaplan‐Meier survival curves showed that patients with profilin‐1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin‐1 levels above the median value (log‐rank test, P |
| doi_str_mv | 10.1111/eci.12839 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1947618509</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1947618509</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-6629c7f82437d3d2cfa30f0ace9fc738184b432eff02751b03513d46e65077323</originalsourceid><addsrcrecordid>eNp10L1OwzAUhmELgWgpDNwAssQCQ6h_EjseUVWgUgVLmS3XOVZd0qTETatuXALXyJVgaGFAwouXR5-OXoTOKbmh8fXB-hvKcq4OUJdykSWMC3aIuoTQNGFKsg46CWFOCMkpZ8eow3KVU5qSLnqczACbEGrrzcrXFa4dXja186WvPt7eKS5hDWXAG7-a4dA2a782JfYVtrOmrrzFL76oYIsLH8AEOEVHzpQBzvZ_Dz3fDSeDh2T8dD8a3I4TyzOuEiGYstLlLOWy4AWzznDiiLGgnJU8p3k6TTkD5wiTGZ0SnlFepAJERqTkjPfQ1W433vraQljphQ8WytJUULdBU5VKQfOMqEgv_9B53TZVvC4qEUOoTJGornfKNnUIDTi9bPzCNFtNif6KrGNk_R052ov9YjtdQPErf6pG0N-BjS9h-_-SHg5Gu8lP332E9Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1968989590</pqid></control><display><type>article</type><title>The association of profilin‐1 levels with survival in chronic kidney disease</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Eroglu, Eray ; Unal, Hilmi U. ; Guclu, Aydin ; Kocyigit, Ismail ; Karaman, Murat ; Saglam, Mutlu ; Gezer, Mustafa ; Tas, Ahmet ; Zararsiz, Gokmen ; Eyileten, Tayfun ; Aydin, İbrahim ; Oguz, Yusuf ; Gungor, Ozkan ; Yilmaz, Mahmut I.</creator><creatorcontrib>Eroglu, Eray ; Unal, Hilmi U. ; Guclu, Aydin ; Kocyigit, Ismail ; Karaman, Murat ; Saglam, Mutlu ; Gezer, Mustafa ; Tas, Ahmet ; Zararsiz, Gokmen ; Eyileten, Tayfun ; Aydin, İbrahim ; Oguz, Yusuf ; Gungor, Ozkan ; Yilmaz, Mahmut I.</creatorcontrib><description>Background
Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1‐5 CKD.
Materials and methods
Serum concentrations of profilin‐1 levels were determined by enzyme‐linked immunosorbent assay. Endothelium‐dependent vasodilatation (flow‐mediated dilatation [FMD]) and endothelium‐independent vasodilatation (nitroglycerine‐mediated dilatation [NMD]) of the brachial artery were assessed noninvasively, using high‐resolution ultrasound.
Results
Both fatal and nonfatal CVE were significantly higher in patients with high profilin‐1 levels. Kaplan‐Meier survival curves showed that patients with profilin‐1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin‐1 levels above the median value (log‐rank test, P < .001).
Conclusions
This is the first study that demonstrates the serum profilin‐1 is independently associated with endothelial dysfunction, cardiovascular events and survival in patients with CKD.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/eci.12839</identifier><identifier>PMID: 28981140</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Actin ; cardiovascular events ; chronic kidney disease ; Cytoskeleton ; endothelial dysfunction ; Endothelium ; Enzyme-linked immunosorbent assay ; Kidney transplantation ; Patients ; Polymerization ; Profilin ; profilin‐1 ; Survival ; Ultrasound ; Vasodilation</subject><ispartof>European journal of clinical investigation, 2017-12, Vol.47 (12), p.n/a</ispartof><rights>2017 Stichting European Society for Clinical Investigation Journal Foundation</rights><rights>2017 Stichting European Society for Clinical Investigation Journal Foundation.</rights><rights>Copyright © 2017 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-6629c7f82437d3d2cfa30f0ace9fc738184b432eff02751b03513d46e65077323</citedby><cites>FETCH-LOGICAL-c3539-6629c7f82437d3d2cfa30f0ace9fc738184b432eff02751b03513d46e65077323</cites><orcidid>0000-0003-2571-7385</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28981140$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eroglu, Eray</creatorcontrib><creatorcontrib>Unal, Hilmi U.</creatorcontrib><creatorcontrib>Guclu, Aydin</creatorcontrib><creatorcontrib>Kocyigit, Ismail</creatorcontrib><creatorcontrib>Karaman, Murat</creatorcontrib><creatorcontrib>Saglam, Mutlu</creatorcontrib><creatorcontrib>Gezer, Mustafa</creatorcontrib><creatorcontrib>Tas, Ahmet</creatorcontrib><creatorcontrib>Zararsiz, Gokmen</creatorcontrib><creatorcontrib>Eyileten, Tayfun</creatorcontrib><creatorcontrib>Aydin, İbrahim</creatorcontrib><creatorcontrib>Oguz, Yusuf</creatorcontrib><creatorcontrib>Gungor, Ozkan</creatorcontrib><creatorcontrib>Yilmaz, Mahmut I.</creatorcontrib><title>The association of profilin‐1 levels with survival in chronic kidney disease</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>Background
Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1‐5 CKD.
Materials and methods
Serum concentrations of profilin‐1 levels were determined by enzyme‐linked immunosorbent assay. Endothelium‐dependent vasodilatation (flow‐mediated dilatation [FMD]) and endothelium‐independent vasodilatation (nitroglycerine‐mediated dilatation [NMD]) of the brachial artery were assessed noninvasively, using high‐resolution ultrasound.
Results
Both fatal and nonfatal CVE were significantly higher in patients with high profilin‐1 levels. Kaplan‐Meier survival curves showed that patients with profilin‐1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin‐1 levels above the median value (log‐rank test, P < .001).
Conclusions
This is the first study that demonstrates the serum profilin‐1 is independently associated with endothelial dysfunction, cardiovascular events and survival in patients with CKD.</description><subject>Actin</subject><subject>cardiovascular events</subject><subject>chronic kidney disease</subject><subject>Cytoskeleton</subject><subject>endothelial dysfunction</subject><subject>Endothelium</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Kidney transplantation</subject><subject>Patients</subject><subject>Polymerization</subject><subject>Profilin</subject><subject>profilin‐1</subject><subject>Survival</subject><subject>Ultrasound</subject><subject>Vasodilation</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp10L1OwzAUhmELgWgpDNwAssQCQ6h_EjseUVWgUgVLmS3XOVZd0qTETatuXALXyJVgaGFAwouXR5-OXoTOKbmh8fXB-hvKcq4OUJdykSWMC3aIuoTQNGFKsg46CWFOCMkpZ8eow3KVU5qSLnqczACbEGrrzcrXFa4dXja186WvPt7eKS5hDWXAG7-a4dA2a782JfYVtrOmrrzFL76oYIsLH8AEOEVHzpQBzvZ_Dz3fDSeDh2T8dD8a3I4TyzOuEiGYstLlLOWy4AWzznDiiLGgnJU8p3k6TTkD5wiTGZ0SnlFepAJERqTkjPfQ1W433vraQljphQ8WytJUULdBU5VKQfOMqEgv_9B53TZVvC4qEUOoTJGornfKNnUIDTi9bPzCNFtNif6KrGNk_R052ov9YjtdQPErf6pG0N-BjS9h-_-SHg5Gu8lP332E9Q</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Eroglu, Eray</creator><creator>Unal, Hilmi U.</creator><creator>Guclu, Aydin</creator><creator>Kocyigit, Ismail</creator><creator>Karaman, Murat</creator><creator>Saglam, Mutlu</creator><creator>Gezer, Mustafa</creator><creator>Tas, Ahmet</creator><creator>Zararsiz, Gokmen</creator><creator>Eyileten, Tayfun</creator><creator>Aydin, İbrahim</creator><creator>Oguz, Yusuf</creator><creator>Gungor, Ozkan</creator><creator>Yilmaz, Mahmut I.</creator><general>Blackwell Publishing Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2571-7385</orcidid></search><sort><creationdate>201712</creationdate><title>The association of profilin‐1 levels with survival in chronic kidney disease</title><author>Eroglu, Eray ; Unal, Hilmi U. ; Guclu, Aydin ; Kocyigit, Ismail ; Karaman, Murat ; Saglam, Mutlu ; Gezer, Mustafa ; Tas, Ahmet ; Zararsiz, Gokmen ; Eyileten, Tayfun ; Aydin, İbrahim ; Oguz, Yusuf ; Gungor, Ozkan ; Yilmaz, Mahmut I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-6629c7f82437d3d2cfa30f0ace9fc738184b432eff02751b03513d46e65077323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Actin</topic><topic>cardiovascular events</topic><topic>chronic kidney disease</topic><topic>Cytoskeleton</topic><topic>endothelial dysfunction</topic><topic>Endothelium</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Kidney transplantation</topic><topic>Patients</topic><topic>Polymerization</topic><topic>Profilin</topic><topic>profilin‐1</topic><topic>Survival</topic><topic>Ultrasound</topic><topic>Vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eroglu, Eray</creatorcontrib><creatorcontrib>Unal, Hilmi U.</creatorcontrib><creatorcontrib>Guclu, Aydin</creatorcontrib><creatorcontrib>Kocyigit, Ismail</creatorcontrib><creatorcontrib>Karaman, Murat</creatorcontrib><creatorcontrib>Saglam, Mutlu</creatorcontrib><creatorcontrib>Gezer, Mustafa</creatorcontrib><creatorcontrib>Tas, Ahmet</creatorcontrib><creatorcontrib>Zararsiz, Gokmen</creatorcontrib><creatorcontrib>Eyileten, Tayfun</creatorcontrib><creatorcontrib>Aydin, İbrahim</creatorcontrib><creatorcontrib>Oguz, Yusuf</creatorcontrib><creatorcontrib>Gungor, Ozkan</creatorcontrib><creatorcontrib>Yilmaz, Mahmut I.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eroglu, Eray</au><au>Unal, Hilmi U.</au><au>Guclu, Aydin</au><au>Kocyigit, Ismail</au><au>Karaman, Murat</au><au>Saglam, Mutlu</au><au>Gezer, Mustafa</au><au>Tas, Ahmet</au><au>Zararsiz, Gokmen</au><au>Eyileten, Tayfun</au><au>Aydin, İbrahim</au><au>Oguz, Yusuf</au><au>Gungor, Ozkan</au><au>Yilmaz, Mahmut I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of profilin‐1 levels with survival in chronic kidney disease</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2017-12</date><risdate>2017</risdate><volume>47</volume><issue>12</issue><epage>n/a</epage><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>Background
Profilin‐1 is a ubiquitous, actin‐binding protein that plays an important role in the regulation of actin polymerization and cytoskeleton remodelling and contributes to vascular dysfunction. We conducted this study to investigate the association of serum profilin‐1 levels with fatal and nonfatal CVE in a cohort of patients with stage 1‐5 CKD.
Materials and methods
Serum concentrations of profilin‐1 levels were determined by enzyme‐linked immunosorbent assay. Endothelium‐dependent vasodilatation (flow‐mediated dilatation [FMD]) and endothelium‐independent vasodilatation (nitroglycerine‐mediated dilatation [NMD]) of the brachial artery were assessed noninvasively, using high‐resolution ultrasound.
Results
Both fatal and nonfatal CVE were significantly higher in patients with high profilin‐1 levels. Kaplan‐Meier survival curves showed that patients with profilin‐1 below the median value (114 pg/mL) had higher cumulative survival compared with patients who had profilin‐1 levels above the median value (log‐rank test, P < .001).
Conclusions
This is the first study that demonstrates the serum profilin‐1 is independently associated with endothelial dysfunction, cardiovascular events and survival in patients with CKD.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>28981140</pmid><doi>10.1111/eci.12839</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2571-7385</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2972 |
| ispartof | European journal of clinical investigation, 2017-12, Vol.47 (12), p.n/a |
| issn | 0014-2972 1365-2362 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1947618509 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Actin cardiovascular events chronic kidney disease Cytoskeleton endothelial dysfunction Endothelium Enzyme-linked immunosorbent assay Kidney transplantation Patients Polymerization Profilin profilin‐1 Survival Ultrasound Vasodilation |
| title | The association of profilin‐1 levels with survival in chronic kidney disease |
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