Terlipressin: Current and emerging indications in chronic liver disease

Terlipressin is an analogue of vasopressin that has potent vasoactive properties and has been available for use in most countries for nearly two decades. It has both established roles and emerging indications in the management of complications of decompensated chronic liver disease. We explore histo...

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Bibliographic Details
Published in:Journal of gastroenterology and hepatology 2018-03, Vol.33 (3), p.591-598
Main Authors: Papaluca, Timothy, Gow, Paul
Format: Article
Language:English
Subjects:
Chronic Disease
Cirrhosis
hepatorenal syndrome
Homeostasis
Humans
Infusions, Intravenous
Liver Circulation - drug effects
Liver cirrhosis
Liver Cirrhosis - drug therapy
Liver Cirrhosis - physiopathology
Liver diseases
Liver Diseases - drug therapy
Liver Diseases - physiopathology
Lypressin - administration & dosage
Lypressin - analogs & derivatives
Lypressin - pharmacology
portal hypertension
Portal Pressure - drug effects
Renal Circulation - drug effects
Sodium
terlipressin
Vasoactive agents
Vasopressin
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Summary:Terlipressin is an analogue of vasopressin that has potent vasoactive properties and has been available for use in most countries for nearly two decades. It has both established roles and emerging indications in the management of complications of decompensated chronic liver disease. We explore historic and emerging literature regarding the use of terlipressin for a range of indications including hepatorenal syndrome, portal hypertensive bleeding, and disruptions in sodium homeostasis. Novel methods of infusion‐based terlipressin administration including the beneficial effect in reduction of adverse events are explored, in addition to new indications for the use of terlipressin in decompensated cirrhosis in an outpatient setting.
ISSN:0815-9319
1440-1746
DOI:10.1111/jgh.14009