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Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel
Yemenite Jews in Israel are a distinctive ethnic division of the Jewish diaspora. Clinical findings, disease course and genetic tests for the LRRK2 6055G > A (G2019S) mutation were compared between Ashkenazi and Yemenite Israeli patients with Parkinson’s disease (PD). Age of onset was significant...
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| Published in: | Journal of Neural Transmission 2008-09, Vol.115 (9), p.1279-1284 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c423t-5cb6c5fb0e42fd79d2aca6dea7ed0a68cbf07ea0e063e4142007a89766e052033 |
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| cites | cdi_FETCH-LOGICAL-c423t-5cb6c5fb0e42fd79d2aca6dea7ed0a68cbf07ea0e063e4142007a89766e052033 |
| container_end_page | 1284 |
| container_issue | 9 |
| container_start_page | 1279 |
| container_title | Journal of Neural Transmission |
| container_volume | 115 |
| creator | Djaldetti, Meir Hassin-Baer, Sharon Vidne, Bernardo A. Yust-Katz, Shlomit Treves, Therese A Melamed, Eldad |
| description | Yemenite Jews in Israel are a distinctive ethnic division of the Jewish diaspora. Clinical findings, disease course and genetic tests for the
LRRK2
6055G > A (G2019S) mutation were compared between Ashkenazi and Yemenite Israeli patients with Parkinson’s disease (PD). Age of onset was significantly younger in the Yemenites (
P
|
| doi_str_mv | 10.1007/s00702-008-0074-z |
| format | article |
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LRRK2
6055G > A (G2019S) mutation were compared between Ashkenazi and Yemenite Israeli patients with Parkinson’s disease (PD). Age of onset was significantly younger in the Yemenites (
P
< 0.001). There were no differences in the distribution of initial symptoms, environmental risk factors or rate of motor/non-motor phenomena. The Yemenite group had a more severe disease (
P
< 0.001), and a more rapid disease course (
P
= 0.006). The frequency of Lrrk2 substitution was 12.7% in the Ashkenazi group and was not observed in the Yemenites. These results show that there are differences between Israeli Jewish ethnic groups in the severity and progression of PD, but not in clinical symptoms. The high frequency of Lrrk2 G2019S in the Ashkenazi and its absence in the Yemenite Jews suggests a specific ancestral pattern of inheritance in Ashkenazi Jews.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/s00702-008-0074-z</identifier><identifier>PMID: 18665323</identifier><identifier>CODEN: JNTRF3</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Age of Onset ; Aged ; Disease Progression ; DNA Mutational Analysis ; Environment ; Female ; Gene Frequency - genetics ; Genetic Predisposition to Disease - ethnology ; Genetic Predisposition to Disease - genetics ; Genetic Testing ; Genotype ; Humans ; Inheritance Patterns - genetics ; Israel - epidemiology ; Jews - ethnology ; Jews - genetics ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mutation - genetics ; Neurology ; Neurosciences ; Parkinson Disease - ethnology ; Parkinson Disease - genetics ; Parkinson Disease - physiopathology ; Parkinson's disease ; Parkinson's Disease and Allied Conditions - Original Article ; Protein-Serine-Threonine Kinases - genetics ; Psychiatry ; Severity of Illness Index ; Yemen - ethnology</subject><ispartof>Journal of Neural Transmission, 2008-09, Vol.115 (9), p.1279-1284</ispartof><rights>Springer-Verlag 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-5cb6c5fb0e42fd79d2aca6dea7ed0a68cbf07ea0e063e4142007a89766e052033</citedby><cites>FETCH-LOGICAL-c423t-5cb6c5fb0e42fd79d2aca6dea7ed0a68cbf07ea0e063e4142007a89766e052033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://igdc.huji.ac.il/home/Maagar/Details.aspx?AN=5638$$D View record in IGDC$$Hfree_for_read</backlink><backlink>$$Uhttps://link.springer.com/article/10.1007%2Fs00702-008-0074-z$$D View full text (Access may be restricted)$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18665323$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Djaldetti, Meir</creatorcontrib><creatorcontrib>Hassin-Baer, Sharon</creatorcontrib><creatorcontrib>Vidne, Bernardo A.</creatorcontrib><creatorcontrib>Yust-Katz, Shlomit</creatorcontrib><creatorcontrib>Treves, Therese A</creatorcontrib><creatorcontrib>Melamed, Eldad</creatorcontrib><title>Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm</addtitle><addtitle>J Neural Transm (Vienna)</addtitle><description>Yemenite Jews in Israel are a distinctive ethnic division of the Jewish diaspora. Clinical findings, disease course and genetic tests for the
LRRK2
6055G > A (G2019S) mutation were compared between Ashkenazi and Yemenite Israeli patients with Parkinson’s disease (PD). Age of onset was significantly younger in the Yemenites (
P
< 0.001). There were no differences in the distribution of initial symptoms, environmental risk factors or rate of motor/non-motor phenomena. The Yemenite group had a more severe disease (
P
< 0.001), and a more rapid disease course (
P
= 0.006). The frequency of Lrrk2 substitution was 12.7% in the Ashkenazi group and was not observed in the Yemenites. These results show that there are differences between Israeli Jewish ethnic groups in the severity and progression of PD, but not in clinical symptoms. The high frequency of Lrrk2 G2019S in the Ashkenazi and its absence in the Yemenite Jews suggests a specific ancestral pattern of inheritance in Ashkenazi Jews.</description><subject>Age of Onset</subject><subject>Aged</subject><subject>Disease Progression</subject><subject>DNA Mutational Analysis</subject><subject>Environment</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>Genetic Predisposition to Disease - ethnology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Testing</subject><subject>Genotype</subject><subject>Humans</subject><subject>Inheritance Patterns - genetics</subject><subject>Israel - epidemiology</subject><subject>Jews - ethnology</subject><subject>Jews - genetics</subject><subject>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Parkinson Disease - ethnology</subject><subject>Parkinson Disease - genetics</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Parkinson's Disease and Allied Conditions - Original Article</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Psychiatry</subject><subject>Severity of Illness Index</subject><subject>Yemen - ethnology</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u1DAURi0EotPCA7BBFgtYBa5_4jhLNCq0qBIsytpynJuMSyYefBOh9ulxNSNVYsXC9sLn-659GHsj4KMAaD5R2UBWALasRlcPz9hGaFVXQhv1nG1AAVRtbfQZOye6AwAhGvuSnQlrTK2k2rDb7RTnGPzEw85nHxbMkZYYiKeB__D5V5wpzR-I95HQE3K_T_PIv-GfSDt-uexKmI85rQficebXlD1Or9iLwU-Er0_nBfv55fJ2e1XdfP96vf18UwUt1VLVoTOhHjpALYe-aXvpgzc9-gZ78MaGboAGPSAYhVpoWT7pbdsYg1BLUOqCvT_2HnL6vSItbh8p4DT5GdNKTrTa6tq2BXz3D3iX1jyXtzlZjChrtC2QOEIhJ6KMgzvkuPf53glwj77d0bcrvt2jb_dQMm9PxWu3x_4pcRJcAHkEqFzNI-anyf_RGsc-uC52U0xj9oddDK42yqq_PImV6A</recordid><startdate>20080901</startdate><enddate>20080901</enddate><creator>Djaldetti, Meir</creator><creator>Hassin-Baer, Sharon</creator><creator>Vidne, Bernardo A.</creator><creator>Yust-Katz, Shlomit</creator><creator>Treves, Therese A</creator><creator>Melamed, Eldad</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>AGDVQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7TK</scope></search><sort><creationdate>20080901</creationdate><title>Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel</title><author>Djaldetti, Meir ; Hassin-Baer, Sharon ; Vidne, Bernardo A. ; Yust-Katz, Shlomit ; Treves, Therese A ; Melamed, Eldad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-5cb6c5fb0e42fd79d2aca6dea7ed0a68cbf07ea0e063e4142007a89766e052033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Age of Onset</topic><topic>Aged</topic><topic>Disease Progression</topic><topic>DNA Mutational Analysis</topic><topic>Environment</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>Genetic Predisposition to Disease - ethnology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic Testing</topic><topic>Genotype</topic><topic>Humans</topic><topic>Inheritance Patterns - genetics</topic><topic>Israel - epidemiology</topic><topic>Jews - ethnology</topic><topic>Jews - genetics</topic><topic>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Neurology</topic><topic>Neurosciences</topic><topic>Parkinson Disease - ethnology</topic><topic>Parkinson Disease - genetics</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Parkinson's Disease and Allied Conditions - Original Article</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Psychiatry</topic><topic>Severity of Illness Index</topic><topic>Yemen - ethnology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Djaldetti, Meir</creatorcontrib><creatorcontrib>Hassin-Baer, Sharon</creatorcontrib><creatorcontrib>Vidne, Bernardo A.</creatorcontrib><creatorcontrib>Yust-Katz, Shlomit</creatorcontrib><creatorcontrib>Treves, Therese A</creatorcontrib><creatorcontrib>Melamed, Eldad</creatorcontrib><collection>IGDC Bibliographic Database - מאגר לחקר ההזדקנות</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of Neural Transmission</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Djaldetti, Meir</au><au>Hassin-Baer, Sharon</au><au>Vidne, Bernardo A.</au><au>Yust-Katz, Shlomit</au><au>Treves, Therese A</au><au>Melamed, Eldad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel</atitle><jtitle>Journal of Neural Transmission</jtitle><stitle>J Neural Transm</stitle><addtitle>J Neural Transm (Vienna)</addtitle><date>2008-09-01</date><risdate>2008</risdate><volume>115</volume><issue>9</issue><spage>1279</spage><epage>1284</epage><pages>1279-1284</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTRF3</coden><abstract>Yemenite Jews in Israel are a distinctive ethnic division of the Jewish diaspora. Clinical findings, disease course and genetic tests for the
LRRK2
6055G > A (G2019S) mutation were compared between Ashkenazi and Yemenite Israeli patients with Parkinson’s disease (PD). Age of onset was significantly younger in the Yemenites (
P
< 0.001). There were no differences in the distribution of initial symptoms, environmental risk factors or rate of motor/non-motor phenomena. The Yemenite group had a more severe disease (
P
< 0.001), and a more rapid disease course (
P
= 0.006). The frequency of Lrrk2 substitution was 12.7% in the Ashkenazi group and was not observed in the Yemenites. These results show that there are differences between Israeli Jewish ethnic groups in the severity and progression of PD, but not in clinical symptoms. The high frequency of Lrrk2 G2019S in the Ashkenazi and its absence in the Yemenite Jews suggests a specific ancestral pattern of inheritance in Ashkenazi Jews.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>18665323</pmid><doi>10.1007/s00702-008-0074-z</doi><tpages>6</tpages></addata></record> |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Age of Onset Aged Disease Progression DNA Mutational Analysis Environment Female Gene Frequency - genetics Genetic Predisposition to Disease - ethnology Genetic Predisposition to Disease - genetics Genetic Testing Genotype Humans Inheritance Patterns - genetics Israel - epidemiology Jews - ethnology Jews - genetics Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Male Medicine Medicine & Public Health Middle Aged Mutation - genetics Neurology Neurosciences Parkinson Disease - ethnology Parkinson Disease - genetics Parkinson Disease - physiopathology Parkinson's disease Parkinson's Disease and Allied Conditions - Original Article Protein-Serine-Threonine Kinases - genetics Psychiatry Severity of Illness Index Yemen - ethnology |
| title | Clinical characteristics of Parkinson's disease among Jewish Ethnic groups in Israel |
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