HIV and malaria co-infection: interactions and consequences of chemotherapy

The global epidemiology of HIV/AIDS and malaria overlap because a significant number of HIV-infected individuals live in regions with different levels of malaria transmission. Although the consequences of co-infection with HIV and malaria parasites are not fully understood, available evidence sugges...

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Bibliographic Details
Published in:Trends in parasitology 2008-06, Vol.24 (6), p.264-271
Main Authors: Skinner-Adams, T.S, McCarthy, J.S, Gardiner, D.L, Andrews, K.T
Format: Article
Language:English
Subjects:
Animals
Anti-HIV Agents - therapeutic use
Antimalarials - therapeutic use
Biological and medical sciences
Comorbidity
Drug Design
Drug Interactions
Gastroenterology and Hepatology
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - transmission
Human immunodeficiency virus
Human protozoal diseases
Humans
Immunocompromised Host
Infectious Disease
Infectious diseases
Malaria
Malaria - drug therapy
Malaria - epidemiology
Malaria - transmission
Medical sciences
Parasitic diseases
Protozoal diseases
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Summary:The global epidemiology of HIV/AIDS and malaria overlap because a significant number of HIV-infected individuals live in regions with different levels of malaria transmission. Although the consequences of co-infection with HIV and malaria parasites are not fully understood, available evidence suggests that the infections act synergistically and together result in worse outcomes. The importance of understanding chemotherapeutic interactions during malaria and HIV co-infection is now being recognized. We know that some antimalarial drugs have weak antiretroviral effects; however, recent studies have also demonstrated that certain antiretroviral agents can inhibit malaria-parasite growth. Here, we discuss recent findings on the impact of HIV/AIDS and malaria co-infection and the possible roles of chemotherapy in improving the treatment of these diseases.
ISSN:1471-4922
1471-5007
DOI:10.1016/j.pt.2008.03.008