Frequency of and Factors Associated With Sexual Dysfunction in Patients With Inflammatory Bowel Disease

• Published in: Journal of Crohn's and colitis 2017-10, Vol.11 (11), p.1347-1352
• Main Authors: Rivière, P, Zallot, C, Desobry, P, Sabaté, J M, Vergniol, J, Zerbib, F, Peyrin-Biroulet, L, Laharie, D, Poullenot, F
• Format: Article
• Language: English
• Subjects: Adult; Case-Control Studies; Colitis, Ulcerative - complications; Crohn Disease - complications; Cross-Sectional Studies; Erectile Dysfunction - epidemiology; Erectile Dysfunction - etiology; Female; Humans; Inflammatory Bowel Diseases - complications; Male; Middle Aged; Sexual Dysfunction, Physiological - epidemiology; Sexual Dysfunction, Physiological - etiology; Surveys and Questionnaires
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjx100

Improvement of quality of life is a main objective in inflammatory bowel disease [IBD] management. Data on sexual dysfunction [SD] in IBD are scarce. This study compared rates of SD between IBD patients and healthy controls [HC], and searched for predictors of SD. All consecutive IBD patients seen in two tertiary centres during 2 months were invited to fill an anonymous validated questionnaire on their sexual function [Female Sexual Index Function and International Index of Erectile Function]. The same questionnaires were filled by HC and by patients with irritable bowel syndrome [IBS] enrolled as a second comparative group. In all, 358 IBD patients filled the questionnaire [192 women]-including 238 with Crohn's disease and 120 with ulcerative colitis-and 110 HC [54 women] and 107 IBS patients [54 women]. In women, SD rates were 53.6% in IBD vs 28% in HC [p < 0.01] and 77.5% in IBS [p = 0.10] patients; in men, figures were 16.9% in IBD, 7.4% in HC [p = 0.64], and 26.4% in IBS [p = 0.60]. An erectile dysfunction [ED] was reported by 43% of IBD patients, 13% of HC [p < 0.01] and 55% of IBS patients [p = 0.60 vs IBD]. Predictors of SD and ED were social and emotional functioning, anxiety in women and depression in men. IBD activity was not associated with SD. In IBD, 54% of women have an SD and 43% of men an ED. These rates are significantly higher than in HC, mostly driven by psychological factors, and independent from disease severity.