Endoscopic and Imaging Predictors of Complete Pathologic Response After Chemoradiation for Esophageal Cancer

Purpose of Review Locally advanced esophageal cancer is frequently treated preoperatively with chemotherapy and radiation. The degree of response to this preoperative therapy varies in different patients, and a complete pathological response (pCR) has important implications in the management and pro...

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Bibliographic Details
Published in:Current gastroenterology reports 2017-11, Vol.19 (11), p.57-57, Article 57
Main Authors: Uberoi, Guneesh S., Uberoi, Angad S., Bhutani, Manoop S.
Format: Article
Language:English
Subjects:
Accuracy
Biomarkers, Tumor - genetics
Biomarkers, Tumor - metabolism
Biopsy
Cancer therapies
Chemoradiotherapy, Adjuvant
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Endoscopy
Endosonography
Esophageal cancer
Esophageal Neoplasms - diagnostic imaging
Esophageal Neoplasms - pathology
Esophageal Neoplasms - therapy
Esophagoscopy
Gastroenterology
GI Oncology (R Bresalier
Humans
Lymphatic system
Medical prognosis
Medicine
Medicine & Public Health
Metastasis
Neoadjuvant Therapy
Patients
Positron Emission Tomography Computed Tomography
Section Editor
Surgery
Topical Collection on GI Oncology
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Summary:Purpose of Review Locally advanced esophageal cancer is frequently treated preoperatively with chemotherapy and radiation. The degree of response to this preoperative therapy varies in different patients, and a complete pathological response (pCR) has important implications in the management and prognosis of these patients. This is a review of the different modalities currently available to detect pCR and the clinical context of their use. Recent Findings While research is still ongoing, no single technique has emerged as the modality of choice to reliably predict pCR in all patients. Studies investigating the sensitivity, specificity, and accuracy of these modalities have had promising results, but no single modality has been firmly validated as the modality if choice. The emergence of functional imaging techniques and the use of biomarkers are newer developments which need further evaluation before adoption in routine clinical practice. Summary While no single technique reliably predicts pCR, a combination of imaging and diagnostic modalities (endoscopic appearance, biopsy, EUS, and PET/CT) may provide a better diagnostic yield rather than any of these modalities taken alone.
ISSN:1522-8037
1534-312X
DOI:10.1007/s11894-017-0594-5