Biological cost of fosfomycin resistance in Escherichia coli in a murine model of urinary tract infection

Prevalence of fosfomycin resistance in E. coli clinical isolates from UTIs remains very low. Our hypothesis was that fosfomycin resistance may be associated with a biological cost. Three groups of strains of E. coli belonging to the B2 phylogenetic group were used: clinical wild-type (WT) isolates,...

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Published in:International journal of medical microbiology 2017-12, Vol.307 (8), p.452-459
Main Authors: Pourbaix, A., Guérin, F., Lastours, V.de, Chau, F., Auzou, M., Boulley, E., Cattoir, V., Fantin, B.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Disease Models, Animal
Drug Resistance, Bacterial
E. coli
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - growth & development
Escherichia coli - pathogenicity
Escherichia coli Infections - drug therapy
Escherichia coli Infections - microbiology
Female
Fitness
Fosfomycin
Fosfomycin - pharmacology
Genetic Fitness
Mice, Inbred CBA
Urinary Tract Infections - drug therapy
Urinary Tract Infections - microbiology
UTI
Virulence
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Summary:Prevalence of fosfomycin resistance in E. coli clinical isolates from UTIs remains very low. Our hypothesis was that fosfomycin resistance may be associated with a biological cost. Three groups of strains of E. coli belonging to the B2 phylogenetic group were used: clinical wild-type (WT) isolates, clinical multidrug-resistant isolates and in vitro fosfomycin-resistant derivatives from the uropathogen clinical strain E. coli CFT073. In each group fosfomycin-susceptible and −resistant isolates were compared. In vitro, we found a significantly decreased growth rate for fosfomycin-resistant strains as compared with susceptible strains in the WT group. In a murine model of ascending UTI, there was a significant reduction in infection rates with fosfomycin-resistant isolates as compared with susceptible ones, in all 3 study groups, ranging from 28 to 39% (P
ISSN:1438-4221
1618-0607
DOI:10.1016/j.ijmm.2017.09.019