Liquid Chromatographic Chiral Separation of Acenocoumarol and Its Hemiketal Form

Abstract Acenocoumarol, an anticoagulant drug, was separated successfully using polysaccharide-based chiral stationary phases columns namely Cellulose Chiralpak® IB and Chiralcel® OD, using various normal mobile phases by high-performance liquid chromatography. However, the appearance of four well s...

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Bibliographic Details
Published in:Journal of chromatographic science 2017-11, Vol.55 (10), p.989-991
Main Authors: Kraimi, Aicha, Belboukhari, Nasser, Sekkoum, Khaled, Cheriti, Abdelkrim, Aboul-Enein, Hassan Y
Format: Article
Language:English
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Summary:Abstract Acenocoumarol, an anticoagulant drug, was separated successfully using polysaccharide-based chiral stationary phases columns namely Cellulose Chiralpak® IB and Chiralcel® OD, using various normal mobile phases by high-performance liquid chromatography. However, the appearance of four well separated peaks confirmed the presence of the hemiketal form of 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-chromen-2-one.
ISSN:0021-9665
1945-239X
DOI:10.1093/chromsci/bmx061