Morphological and morphometrical changes on adult Wistar rat testis caused by chronic sodium arsenite exposure

Arsenic is a contaminant that occurs naturally in the environment, and it is related to several diseases, such as cancer and severe metabolic diseases. Sodium arsenite effects on testes rats are not fully understood regarding morphology and stereology; thus, it becomes necessary to evaluate possible...

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Bibliographic Details
Published in:Environmental science and pollution research international 2017-12, Vol.24 (36), p.27905-27912
Main Authors: de Araújo Ramos, Anderson Tadeu, Diamante, Maria Aparecida Silva, de Almeida Lamas, Celina, Dolder, Heidi, de Souza Predes, Fabrícia
Format: Article
Language:English
Subjects:
Aquatic Pollution
Arsenic
Arsenite
Atmospheric Protection/Air Quality Control/Air Pollution
Cancer
Cell activation
Contaminants
Earth and Environmental Science
Ecotoxicology
Environment
Environmental Chemistry
Environmental Health
Environmental science
Exposure
Immunology
Low concentrations
Macrophages
Metabolic disorders
Metabolism
Occupational exposure
Occupational health
Organs
Oxidative stress
Rats
Research Article
Seminiferous tubule
Sodium
Sodium arsenite
Spermatozoa
Stereology
Steroidogenesis
Testes
Testosterone
Waste Water Technology
Water Management
Water Pollution Control
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Summary:Arsenic is a contaminant that occurs naturally in the environment, and it is related to several diseases, such as cancer and severe metabolic diseases. Sodium arsenite effects on testes rats are not fully understood regarding morphology and stereology; thus, it becomes necessary to evaluate possible changes in these parameters under low concentrations and simulating occupational exposure. Therefore, the aim of this study was to analyze the morphometrical and stereological changes on rat testis treated with sodium arsenite. The treatment was accomplished using 5 mg/kg of sodium arsenite by gastric gavage in Wistar rats, which experiment lasted 8 weeks. Organs were weighed and gonadosomatic index (GSI) was calculated. Using the software Image Pro Plus, seminiferous tubule diameter was measured, and the volume densities of testicular parenchymal components were obtained. It was counted 200 hundred spermatozoa and classified as normal or abnormal. The parameters means of control ( N  = 5) and treated ( N  = 7) groups were compared by U Mann-Whitney’s test, and the results were considered significant for P  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-017-0200-2