Autoimmune Regulator (AIRE) Gene Is Expressed in Human Activated CD4 super(+) T-Cells and Regulated by Mitogen-Activated Protein Kinase Pathway

The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated pro...

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Bibliographic Details
Published in:Microbiology and immunology 2006-01, Vol.50 (12), p.979-987
Main Authors: Nagafuchi, Seiho, Katsuta, Hitoshi, Koyanagi-Katsuta, Rimiko, Yamasaki, Satoshi, Inoue, Yasushi, Shimoda, Kazuya, Ikeda, Yukari, Shindo, Mieko, Yoshida, Eiko, Matsuo, Tomohito, Ohno, Yuju, Kogawa, Kazuhiko, Anzai, Keizo, Kurisaki, Hironori, Kudoh, Jun, Harada, Mine, Shimizu, Nobuyoshi
Format: Article
Language:English
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Summary:The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen- and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system.
ISSN:0385-5600
1348-0421