Design and development of polysaccharide hemostatic materials and their hemostatic mechanism

The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body's own coagulation process is not able to accomplish timely hemostasis without the assistance of hemostatic agents. For developing novel topical hemosta...

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Bibliographic Details
Published in:Biomaterials science 2017-11, Vol.5 (12), p.2357-2368
Main Authors: Yang, Xiao, Liu, Wen, Li, Na, Wang, Mingshan, Liang, Bin, Ullah, Ihsan, Luis Neve, Agnaldo, Feng, Yakai, Chen, Hao, Shi, Changcan
Format: Article
Language:English
Subjects:
Administration, Topical
Antiinfectives and antibacterials
Biocompatibility
Biodegradability
Bleeding
Blood Coagulation - drug effects
Blood Coagulation - physiology
Coagulation
Hemorrhage - drug therapy
Hemorrhage - pathology
Hemostasis - drug effects
Hemostatics
Hemostatics - chemistry
Humans
Microorganisms
Polysaccharides
Polysaccharides - chemistry
Polysaccharides - therapeutic use
Sealants
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Summary:The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body's own coagulation process is not able to accomplish timely hemostasis without the assistance of hemostatic agents. For developing novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and the hemostasis mechanism of different materials. Among hemostatic materials, polysaccharides are naturally derived polymers having excellent biodegradable and biocompatible properties. This review provides an overview of polysaccharide-based hemostatic materials and agents, including their advantages and drawbacks in hemostatic applications. Furthermore, polysaccharide-based hemostatic materials with anti-microbial and healing functions are also introduced. The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding.
ISSN:2047-4830
2047-4849
DOI:10.1039/c7bm00554g