Concentration-dependent protein adsorption at the nano-bio interfaces of polymeric nanoparticles and serum proteins

A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2017-11, Vol.12 (22), p.2757-2769
Main Authors: Zhang, Tian-Xu, Zhu, Guan-Yin, Lu, Bo-Yao, Zhang, Chao-Liang, Peng, Qiang
Format: Article
Language:English
Subjects:
3-Hydroxybutyric Acid - chemistry
Adsorption
Blood Proteins - chemistry
Caproates - chemistry
Chemistry, Pharmaceutical
drug delivery
Drug Delivery Systems
Humans
Microscopy
Nanomaterials
Nanomedicine
Nanoparticles
Nanoparticles - chemistry
Particle Size
PHBHHx
Protein Binding
protein corona
Protein Corona - chemistry
Proteins
Surface Properties
Theranostic Nanomedicine - methods
theranostics
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Summary:A comprehensive understanding of nanoparticle (NP)-protein interaction (protein corona formation) is required. So far, many factors influencing this interaction have been investigated, like size and ζ potential. However, NPs exposure concentration has always been ignored. Herein, we aim to disclose the correlation of NPs exposure concentration with protein adsorption. Four polymeric NPs systems possessing similar sizes (230 ± 20 nm) but varied ζ potentials (−30 ∼ +40 mv) were prepared. Physicochemical properties and protein adsorption upon NP-protein interaction were characterized. Protein adsorption capacity and adsorbed protein types were NPs concentration-dependent. Considering the critical impacts of protein adsorption on NPs delivery, our work could be an urgent warning about the possible risks of dosage adjustment of nanoformulations.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2017-0238