The effect of low-level laser therapy on orthodontically induced root resorption: a pilot double blind randomized controlled trial

• Published in: European journal of orthodontics 2018-05, Vol.40 (3), p.317-325
• Main Authors: Ng, Doreen, Chan, Ambrose K, Papadopoulou, Alexandra K, Dalci, Oyku, Petocz, Peter, Darendeliler, Mehmet Ali
• Format: Article
• Language: English
• Subjects: Adolescent; Bicuspid - pathology; Bicuspid - radiation effects; Dentistry; Double-Blind Method; Female; Humans; Low-Level Light Therapy - methods; Male; Pilot Projects; Radiotherapy Dosage; Root Resorption - etiology; Root Resorption - pathology; Root Resorption - prevention & control; Tooth Movement Techniques - adverse effects; Tooth Movement Techniques - methods
• ISSN: 0141-5387; 1460-2210
• DOI: 10.1093/ejo/cjx065

Summary Background The effect of low-level laser therapy (LLLT) on accelerating orthodontic tooth movement has been extensively studied; however, there is limited knowledge on the use of LLLT on orthodontic root resorption. Objective To investigate the effect of LLLT on orthodontically induced inflammatory root resorption (OIIRR) and to compare the difference between pulsed and continuous LLLT on OIIRR. Trial design Double-blind, single-centre 3-arm parallel split-mouth randomized controlled trial. Participants Twenty adolescent patients who required bilateral maxillary first premolar (MFP) orthodontic extractions were recruited from the Sydney Dental Hospital between October 2014 and December 2014. Intervention All MFPs were tipped buccally for 28 days to induce OIIRR. The experimental premolars (n = 20) received LLLT and the control premolars (n = 20) received placebo-laser on days 0, 1, 2, 3, 7, 14, and 21. Ten experimental premolars received LLLT via continuous delivery and 10 received pulsed delivery. Laser parameter AlGaAs diode laser of 808 nm wavelength, 0.18 W power, 1.6 J per point, and duration of 9s for continuous mode and 4.5 s for pulsed mode. Outcome The difference in root resorption crater volume between LLLT and placebo-laser and continuous or pulsed laser delivery after 28 days. Randomization Randomization was computer-generated, with allocation concealment by opaque sequentially numbered sealed envelopes. Blinding The participants and operator were blinded. Results Eighty-eight patients were screened and 20 patients were randomized. Forty premolars were analysed. LLLT resulted in 23 per cent less root resorption compared to the placebo (P = 0.026). Pulsed laser delivery resulted in 5 per cent less root resorption than continuous; however, this was not statistically significant (P = 0.823). No harm was observed. Conclusion Teeth treated with LLLT had less total root resorption than placebo-laser. Furthermore, there was minimal difference between pulsed or continuous delivery of LLLT. Trial Registration Clinical Trials Registry (ACTRN12616000829415). Protocol The protocol was not published before trial commencement.