Development of human striatal anlagen after transplantation in a patient with Huntington's disease

Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation o...

Full description

Saved in:
Bibliographic Details
Published in:Experimental neurology 2008-09, Vol.213 (1), p.241-244
Main Authors: Gallina, Pasquale, Paganini, Marco, Lombardini, Letizia, Saccardi, Riccardo, Marini, Mirca, De Cristofaro, Maria Teresa, Pinzani, Pamela, Salvianti, Francesca, Crescioli, Clara, Di Rita, Andrea, Bucciantini, Sandra, Mechi, Claudia, Sarchielli, Erica, Moretti, Marco, Piacentini, Silvia, Gritti, Gaetano, Bosi, Alberto, Sorbi, Sandro, Orlandini, Giovanni, Vannelli, Gabriella B., Di Lorenzo, Nicola
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain Tissue Transplantation - methods
Cells, Cultured
Corpus Striatum - embryology
Corpus Striatum - metabolism
Corpus Striatum - transplantation
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Energy Metabolism - physiology
Female
Fetal striatal tissue
Fetal Tissue Transplantation - methods
Functional Laterality - physiology
Graft Survival - physiology
Humans
Huntington Disease - pathology
Huntington Disease - physiopathology
Huntington Disease - therapy
Huntington's disease
Magnetic Resonance Imaging
Medical sciences
Neuroblasts
Neurology
Neuronal Plasticity - physiology
Neuronavigation
Neurotransplantation
Positron-Emission Tomography
Restoration
Stereotaxic Techniques
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first “ in vivo” demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2008.06.003