Hydrazone, Amide, Carbamate, Macromolecular and Other Prodrugs of Doxorubicin

An important strategy for improving the antitumor selectivity and decreasing severe side effect of antitumor agents is to design carrier systems and prodrugs. Here, we review the most important prodrug models based on doxorubicin.

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Bibliographic Details
Published in:The open drug delivery journal 2008-10, Vol.2 (1), p.77-85
Main Authors: Rollas, Sevim, Kucukguzel, S. Guniz
Format: Article
Language:English
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Description
Summary:An important strategy for improving the antitumor selectivity and decreasing severe side effect of antitumor agents is to design carrier systems and prodrugs. Here, we review the most important prodrug models based on doxorubicin.
ISSN:1874-1266
1874-1266
DOI:10.2174/1874126600802010077