Effects of N-acetylcysteine on isolated skeletal muscle contractile properties after an acute bout of aerobic exercise

The current study tested the hypotheses that 1) an acute bout of aerobic exercise impairs isolated skeletal muscle contractile properties and 2) N-acetylcysteine (a thiol antioxidant; NAC) administration can restore the impaired muscle contractility after exercise. At rest or immediately after an ac...

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Bibliographic Details
Published in:Life sciences (1973) 2017-12, Vol.191, p.46-51
Main Authors: Jannig, Paulo R., Alves, Christiano R.R., Voltarelli, Vanessa A., Bozi, Luiz H.M., Vieira, Janaina S., Brum, Patricia C., Bechara, Luiz R.G.
Format: Article
Language:English
Subjects:
Acetylcysteine
Acetylcysteine - pharmacology
Aerobics
Animals
Antioxidants
Antioxidants - pharmacology
Effects
Exercise
Fatigue
Force
Male
Muscle contraction
Muscle Contraction - drug effects
Muscle Fatigue - drug effects
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Muscles
Muscular fatigue
N-acetylcysteine
Physical Conditioning, Animal - adverse effects
Properties (attributes)
Rats
Rats, Wistar
Redox signaling
Skeletal muscle
Skeletal system
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Summary:The current study tested the hypotheses that 1) an acute bout of aerobic exercise impairs isolated skeletal muscle contractile properties and 2) N-acetylcysteine (a thiol antioxidant; NAC) administration can restore the impaired muscle contractility after exercise. At rest or immediately after an acute bout of aerobic exercise, extensor digitorum longus (EDL) and soleus muscles from male Wistar rats were harvested for ex vivo skeletal muscle contraction experiments. Muscles from exercised animals were incubated in Krebs Ringer's buffer in absence or presence of 20mM of NAC. Force capacity and fatigue properties were evaluated. Exercised EDL and soleus displayed lower force production across various stimulation frequencies (p
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2017.10.012