3D printing hydrogel with graphene oxide is functional in cartilage protection by influencing the signal pathway of Rank/Rankl/OPG

• Published in: Materials Science & Engineering C 2018-01, Vol.82, p.244-252
• Main Authors: Cheng, Zhong, Landish, Bolaky, Chi, Zhang, Nannan, Cui, Jingyu, Du, Sen, Lu, Xiangjin, Lin
• Format: Article
• Language: English
• Subjects: 3-D printers; 3D printing; Animals; Biocompatible Materials - chemistry; Biocompatible Materials - pharmacology; Biomaterials; Biomedical materials; Bone Morphogenetic Protein 7 - chemistry; Bone Morphogenetic Protein 7 - metabolism; Bone Morphogenetic Protein 7 - pharmacology; Cartilage; Cartilage - drug effects; Cartilage - metabolism; Cell Line; Cell Survival - drug effects; Chondrocytes; Chondrocytes - cytology; Chondrocytes - drug effects; Chondrocytes - metabolism; Drug Carriers - chemistry; Drug delivery systems; Drugs; Graphene; Graphene oxide; Graphite - chemistry; Humans; Hydrogels; Hydrogels - chemistry; Male; Materials science; Nanoparticles; Nanoparticles - chemistry; Osteoprotegerin; Osteoprotegerin - metabolism; Oxides - chemistry; Printing; Rank; RANK Ligand - metabolism; Rats; Rats, Sprague-Dawley; Receptor Activator of Nuclear Factor-kappa B - metabolism; Signal Transduction - drug effects; Studies; Three dimensional composites; Three dimensional printing; Tissue Scaffolds - chemistry; TRANCE protein
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2017.08.069

3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate. Graphene oxide nanoparticles (GO-np) have been used as a delivery vehicle for small molecule drugs in order to investigate the state of GO-np within 3D tissue constructs in terms of a composite 3D printing scaffold, which in turn is relevant to the protection of cartilage. We transplanted rats with hydrogel/GO-np and hydrogel, which in turn showed that hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG. Those findings indicated that GO-np may be potentially used to control the release of carrier materials and influence the signal pathway of Rank/Rankl/OPG. •3Dprinting is defined as the use of printing technology to deposit living cells, and biomaterials on a given /a substrate.•Graphene oxide nano particels (GO-np) have been used as a delivery vehicle.•Hydrogel/GO-np protected the tissue of cartilage by the signal pathway of Rank/Rankl/OPG.