Molecular afterglow imaging with bright, biodegradable polymer nanoparticles

Ultra-high signal-to-background in vivo imaging is enabled by biocompatible semiconducting polymer nanoparticles. Afterglow optical agents, which emit light long after cessation of excitation, hold promise for ultrasensitive in vivo imaging because they eliminate tissue autofluorescence. However, af...

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Bibliographic Details
Published in:Nature biotechnology 2017-11, Vol.35 (11), p.1102-1110
Main Authors: Miao, Qingqing, Xie, Chen, Zhen, Xu, Lyu, Yan, Duan, Hongwei, Liu, Xiaogang, Jokerst, Jesse V, Pu, Kanyi
Format: Article
Language:English
Subjects:
14/33
14/34
14/5
639/301/357/354
639/925/350/59
639/925/352/2734
64/60
9/10
Agriculture
Animals
Biodegradability
Biodegradable Plastics
Biodegradation
Bioinformatics
Biomedical Engineering/Biotechnology
Biomedicine
Biopolymers
Biotechnology
Defects
Diagnostic Imaging
Fluorescence
HeLa Cells
Hepatotoxicity
Humans
I.R. radiation
Imaging
Life Sciences
Light
Luminescent Agents
Lymph nodes
Mice
Mice, Nude
Nanoparticles
Near infrared radiation
Neoplasms, Experimental
Optical properties
Polymers
Quantum Dots - chemistry
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Summary:Ultra-high signal-to-background in vivo imaging is enabled by biocompatible semiconducting polymer nanoparticles. Afterglow optical agents, which emit light long after cessation of excitation, hold promise for ultrasensitive in vivo imaging because they eliminate tissue autofluorescence. However, afterglow imaging has been limited by its reliance on inorganic nanoparticles with relatively low brightness and short-near-infrared (NIR) emission. Here we present semiconducting polymer nanoparticles (SPNs)
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt.3987