New Polymorph Form of Dexamethasone Acetate

A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic reson...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 2018-02, Vol.107 (2), p.672-681
Main Authors: Silva, Ronaldo Pedro da, Ambrósio, Mateus Felipe Schuchter, Piovesan, Luciana Almeida, Freitas, Maria Clara Ramalho, Aguiar, Daniel Lima Marques de, Horta, Bruno Araújo Cautiero, Epprecht, Eugenio Kahn, San Gil, Rosane Aguiar da Silva, Visentin, Lorenzo do Canto
Format: Article
Language:English
Subjects:
crystal structure
molecular modeling
polymorph
X-ray polycrystal diffractometry and C-13 CPMAS NMR
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Summary:A new monohydrated polymorph of dexamethasone acetate was crystallized and its crystal structure characterized. The different analytical techniques used for describing its structural and vibrational properties were: single crystal and polycrystal X-ray diffraction, solid state nuclear magnetic resonance, infrared spectroscopy. A Hirshfeld surface analysis was carried out through self-arrangement cemented by H-bonds observed in this new polymorph. This new polymorph form appeared because of self-arrangement via classical hydrogen bonds around the water molecule.
ISSN:0022-3549
1520-6017
DOI:10.1016/j.xphs.2017.10.001