Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study

Background Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk. Objectives In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorph...

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Published in:Pediatric pulmonology 2017-12, Vol.52 (12), p.1592-1598
Main Authors: Abouzeid, Heba, Alkholy, Usama M., Abdou, Mohammed A., Morsy, Saeed M., Abdelrahman, Hind M., Sherif, Ashraf M., Abdalmonem, Nermin, Hamed, Mohammed E., Allah, Mayy A.N., Al Morshedy, Salah, Elashkar, Shaimaa S.A., Noah, Maha A., Hegab, Mohamed S., Akeel, Nagwa E., Hashem, Mustafa I.A., Gawish, Heba H., Fattah, Lobna Abdel
Format: Article
Language:English
Subjects:
Alleles
angiotensin‐converting enzyme
Case-Control Studies
Child
Child, Preschool
children
community acquired pneumonia
Community-Acquired Infections - blood
Community-Acquired Infections - epidemiology
Community-Acquired Infections - genetics
Egypt - epidemiology
Enzymes
Female
gene polymorphism
Genetic Predisposition to Disease
Genotype
Humans
Male
Peptidyl-Dipeptidase A - blood
Peptidyl-Dipeptidase A - genetics
Pneumonia - blood
Pneumonia - epidemiology
Pneumonia - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Prospective Studies
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Summary:Background Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk. Objectives In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism. Methods This was a prospective case‐control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP), while the serum ACE levels were measured by ELISA. Results Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14‐4.35] for the DD genotype; P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.23886