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Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study
Background Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk. Objectives In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorph...
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| Published in: | Pediatric pulmonology 2017-12, Vol.52 (12), p.1592-1598 |
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| container_title | Pediatric pulmonology |
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| creator | Abouzeid, Heba Alkholy, Usama M. Abdou, Mohammed A. Morsy, Saeed M. Abdelrahman, Hind M. Sherif, Ashraf M. Abdalmonem, Nermin Hamed, Mohammed E. Allah, Mayy A.N. Al Morshedy, Salah Elashkar, Shaimaa S.A. Noah, Maha A. Hegab, Mohamed S. Akeel, Nagwa E. Hashem, Mustafa I.A. Gawish, Heba H. Fattah, Lobna Abdel |
| description | Background
Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk.
Objectives
In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism.
Methods
This was a prospective case‐control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP), while the serum ACE levels were measured by ELISA.
Results
Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14‐4.35] for the DD genotype; P |
| doi_str_mv | 10.1002/ppul.23886 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1951570138</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1965156520</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3576-e5e69c6737d2265efbedb784c25939749451b022793c291ceff4d961791ca3593</originalsourceid><addsrcrecordid>eNp90cFq3DAQBmBRWppN2ksfoAh6CQEnkmxJVm7LkjSFhe6hORuvPN5VkCVXshOcUx-hz5gnqTZOe8ihJw2aj5-BH6FPlJxTQthF34_2nOVlKd6gBSVKZaRQ4i1alJLzTJQiP0LHMd4RknaKvkdHTBFWUkEW6HHpdsYP4KJxT79-a-_uIQzG7TC4x6kDbFw8fHh30YCFw4B34AD33k6dD_3exC4hfLWb-sHUDuu9sU0Ahx_MsMer5eYSL7GuI8zxQ_AWx2Fspg_oXVvbCB9f3hN0e331Y3WTrb9__bZarjOdcyky4CCUFjKXDWOCQ7uFZivLQjOuciULVXC6JYxJlWumqIa2LRolqExznSdzgk7n3D74nyPEoepM1GBt7cCPsaKKUy4JzctEv7yid34MLl2XlEhMcEaSOpuVDj7GAG3VB9PVYaooqQ6NVIdGqudGEv78EjluO2j-0b8VJEBn8GAsTP-Jqjab2_Uc-gey0Jlx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1965156520</pqid></control><display><type>article</type><title>Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Abouzeid, Heba ; Alkholy, Usama M. ; Abdou, Mohammed A. ; Morsy, Saeed M. ; Abdelrahman, Hind M. ; Sherif, Ashraf M. ; Abdalmonem, Nermin ; Hamed, Mohammed E. ; Allah, Mayy A.N. ; Al Morshedy, Salah ; Elashkar, Shaimaa S.A. ; Noah, Maha A. ; Hegab, Mohamed S. ; Akeel, Nagwa E. ; Hashem, Mustafa I.A. ; Gawish, Heba H. ; Fattah, Lobna Abdel</creator><creatorcontrib>Abouzeid, Heba ; Alkholy, Usama M. ; Abdou, Mohammed A. ; Morsy, Saeed M. ; Abdelrahman, Hind M. ; Sherif, Ashraf M. ; Abdalmonem, Nermin ; Hamed, Mohammed E. ; Allah, Mayy A.N. ; Al Morshedy, Salah ; Elashkar, Shaimaa S.A. ; Noah, Maha A. ; Hegab, Mohamed S. ; Akeel, Nagwa E. ; Hashem, Mustafa I.A. ; Gawish, Heba H. ; Fattah, Lobna Abdel</creatorcontrib><description>Background
Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk.
Objectives
In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism.
Methods
This was a prospective case‐control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP), while the serum ACE levels were measured by ELISA.
Results
Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14‐4.35] for the DD genotype; P < 0.001) and (OR: 1.8; [95%CI: 1.42‐2.29]; for the D allele; P < 0.01, respectively). Patients with the DD genotype had significantly higher mean serum ACE levels (45.6 ± 11.4 U/L) compared to those with ID genotype (36.5 ± 8.3 U/L) and II genotype (21.6 ± 5.7 U/L); P < 0.01, respectively.
Conclusion
The ACE I/D polymorphism (rs4340) may contribute to the genetic susceptibility of CAP in Egyptian children. The ACE D allele and DD genotype were associated with higher serum ACE levels among studied CAP patients.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.23886</identifier><identifier>PMID: 29028160</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Alleles ; angiotensin‐converting enzyme ; Case-Control Studies ; Child ; Child, Preschool ; children ; community acquired pneumonia ; Community-Acquired Infections - blood ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - genetics ; Egypt - epidemiology ; Enzymes ; Female ; gene polymorphism ; Genetic Predisposition to Disease ; Genotype ; Humans ; Male ; Peptidyl-Dipeptidase A - blood ; Peptidyl-Dipeptidase A - genetics ; Pneumonia - blood ; Pneumonia - epidemiology ; Pneumonia - genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Prospective Studies</subject><ispartof>Pediatric pulmonology, 2017-12, Vol.52 (12), p.1592-1598</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3576-e5e69c6737d2265efbedb784c25939749451b022793c291ceff4d961791ca3593</citedby><cites>FETCH-LOGICAL-c3576-e5e69c6737d2265efbedb784c25939749451b022793c291ceff4d961791ca3593</cites><orcidid>0000-0002-7898-3006</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29028160$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abouzeid, Heba</creatorcontrib><creatorcontrib>Alkholy, Usama M.</creatorcontrib><creatorcontrib>Abdou, Mohammed A.</creatorcontrib><creatorcontrib>Morsy, Saeed M.</creatorcontrib><creatorcontrib>Abdelrahman, Hind M.</creatorcontrib><creatorcontrib>Sherif, Ashraf M.</creatorcontrib><creatorcontrib>Abdalmonem, Nermin</creatorcontrib><creatorcontrib>Hamed, Mohammed E.</creatorcontrib><creatorcontrib>Allah, Mayy A.N.</creatorcontrib><creatorcontrib>Al Morshedy, Salah</creatorcontrib><creatorcontrib>Elashkar, Shaimaa S.A.</creatorcontrib><creatorcontrib>Noah, Maha A.</creatorcontrib><creatorcontrib>Hegab, Mohamed S.</creatorcontrib><creatorcontrib>Akeel, Nagwa E.</creatorcontrib><creatorcontrib>Hashem, Mustafa I.A.</creatorcontrib><creatorcontrib>Gawish, Heba H.</creatorcontrib><creatorcontrib>Fattah, Lobna Abdel</creatorcontrib><title>Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study</title><title>Pediatric pulmonology</title><addtitle>Pediatr Pulmonol</addtitle><description>Background
Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk.
Objectives
In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism.
Methods
This was a prospective case‐control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP), while the serum ACE levels were measured by ELISA.
Results
Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14‐4.35] for the DD genotype; P < 0.001) and (OR: 1.8; [95%CI: 1.42‐2.29]; for the D allele; P < 0.01, respectively). Patients with the DD genotype had significantly higher mean serum ACE levels (45.6 ± 11.4 U/L) compared to those with ID genotype (36.5 ± 8.3 U/L) and II genotype (21.6 ± 5.7 U/L); P < 0.01, respectively.
Conclusion
The ACE I/D polymorphism (rs4340) may contribute to the genetic susceptibility of CAP in Egyptian children. The ACE D allele and DD genotype were associated with higher serum ACE levels among studied CAP patients.</description><subject>Alleles</subject><subject>angiotensin‐converting enzyme</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>community acquired pneumonia</subject><subject>Community-Acquired Infections - blood</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - genetics</subject><subject>Egypt - epidemiology</subject><subject>Enzymes</subject><subject>Female</subject><subject>gene polymorphism</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Peptidyl-Dipeptidase A - blood</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Pneumonia - blood</subject><subject>Pneumonia - epidemiology</subject><subject>Pneumonia - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Prospective Studies</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp90cFq3DAQBmBRWppN2ksfoAh6CQEnkmxJVm7LkjSFhe6hORuvPN5VkCVXshOcUx-hz5gnqTZOe8ihJw2aj5-BH6FPlJxTQthF34_2nOVlKd6gBSVKZaRQ4i1alJLzTJQiP0LHMd4RknaKvkdHTBFWUkEW6HHpdsYP4KJxT79-a-_uIQzG7TC4x6kDbFw8fHh30YCFw4B34AD33k6dD_3exC4hfLWb-sHUDuu9sU0Ahx_MsMer5eYSL7GuI8zxQ_AWx2Fspg_oXVvbCB9f3hN0e331Y3WTrb9__bZarjOdcyky4CCUFjKXDWOCQ7uFZivLQjOuciULVXC6JYxJlWumqIa2LRolqExznSdzgk7n3D74nyPEoepM1GBt7cCPsaKKUy4JzctEv7yid34MLl2XlEhMcEaSOpuVDj7GAG3VB9PVYaooqQ6NVIdGqudGEv78EjluO2j-0b8VJEBn8GAsTP-Jqjab2_Uc-gey0Jlx</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Abouzeid, Heba</creator><creator>Alkholy, Usama M.</creator><creator>Abdou, Mohammed A.</creator><creator>Morsy, Saeed M.</creator><creator>Abdelrahman, Hind M.</creator><creator>Sherif, Ashraf M.</creator><creator>Abdalmonem, Nermin</creator><creator>Hamed, Mohammed E.</creator><creator>Allah, Mayy A.N.</creator><creator>Al Morshedy, Salah</creator><creator>Elashkar, Shaimaa S.A.</creator><creator>Noah, Maha A.</creator><creator>Hegab, Mohamed S.</creator><creator>Akeel, Nagwa E.</creator><creator>Hashem, Mustafa I.A.</creator><creator>Gawish, Heba H.</creator><creator>Fattah, Lobna Abdel</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7898-3006</orcidid></search><sort><creationdate>201712</creationdate><title>Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study</title><author>Abouzeid, Heba ; Alkholy, Usama M. ; Abdou, Mohammed A. ; Morsy, Saeed M. ; Abdelrahman, Hind M. ; Sherif, Ashraf M. ; Abdalmonem, Nermin ; Hamed, Mohammed E. ; Allah, Mayy A.N. ; Al Morshedy, Salah ; Elashkar, Shaimaa S.A. ; Noah, Maha A. ; Hegab, Mohamed S. ; Akeel, Nagwa E. ; Hashem, Mustafa I.A. ; Gawish, Heba H. ; Fattah, Lobna Abdel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-e5e69c6737d2265efbedb784c25939749451b022793c291ceff4d961791ca3593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Alleles</topic><topic>angiotensin‐converting enzyme</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>community acquired pneumonia</topic><topic>Community-Acquired Infections - blood</topic><topic>Community-Acquired Infections - epidemiology</topic><topic>Community-Acquired Infections - genetics</topic><topic>Egypt - epidemiology</topic><topic>Enzymes</topic><topic>Female</topic><topic>gene polymorphism</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Peptidyl-Dipeptidase A - blood</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Pneumonia - blood</topic><topic>Pneumonia - epidemiology</topic><topic>Pneumonia - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Prospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abouzeid, Heba</creatorcontrib><creatorcontrib>Alkholy, Usama M.</creatorcontrib><creatorcontrib>Abdou, Mohammed A.</creatorcontrib><creatorcontrib>Morsy, Saeed M.</creatorcontrib><creatorcontrib>Abdelrahman, Hind M.</creatorcontrib><creatorcontrib>Sherif, Ashraf M.</creatorcontrib><creatorcontrib>Abdalmonem, Nermin</creatorcontrib><creatorcontrib>Hamed, Mohammed E.</creatorcontrib><creatorcontrib>Allah, Mayy A.N.</creatorcontrib><creatorcontrib>Al Morshedy, Salah</creatorcontrib><creatorcontrib>Elashkar, Shaimaa S.A.</creatorcontrib><creatorcontrib>Noah, Maha A.</creatorcontrib><creatorcontrib>Hegab, Mohamed S.</creatorcontrib><creatorcontrib>Akeel, Nagwa E.</creatorcontrib><creatorcontrib>Hashem, Mustafa I.A.</creatorcontrib><creatorcontrib>Gawish, Heba H.</creatorcontrib><creatorcontrib>Fattah, Lobna Abdel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abouzeid, Heba</au><au>Alkholy, Usama M.</au><au>Abdou, Mohammed A.</au><au>Morsy, Saeed M.</au><au>Abdelrahman, Hind M.</au><au>Sherif, Ashraf M.</au><au>Abdalmonem, Nermin</au><au>Hamed, Mohammed E.</au><au>Allah, Mayy A.N.</au><au>Al Morshedy, Salah</au><au>Elashkar, Shaimaa S.A.</au><au>Noah, Maha A.</au><au>Hegab, Mohamed S.</au><au>Akeel, Nagwa E.</au><au>Hashem, Mustafa I.A.</au><au>Gawish, Heba H.</au><au>Fattah, Lobna Abdel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr Pulmonol</addtitle><date>2017-12</date><risdate>2017</risdate><volume>52</volume><issue>12</issue><spage>1592</spage><epage>1598</epage><pages>1592-1598</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><abstract>Background
Community‐acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin‐converting enzyme (ACE) gene is a potential candidate gene for CAP risk.
Objectives
In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism.
Methods
This was a prospective case‐control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP), while the serum ACE levels were measured by ELISA.
Results
Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14‐4.35] for the DD genotype; P < 0.001) and (OR: 1.8; [95%CI: 1.42‐2.29]; for the D allele; P < 0.01, respectively). Patients with the DD genotype had significantly higher mean serum ACE levels (45.6 ± 11.4 U/L) compared to those with ID genotype (36.5 ± 8.3 U/L) and II genotype (21.6 ± 5.7 U/L); P < 0.01, respectively.
Conclusion
The ACE I/D polymorphism (rs4340) may contribute to the genetic susceptibility of CAP in Egyptian children. The ACE D allele and DD genotype were associated with higher serum ACE levels among studied CAP patients.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29028160</pmid><doi>10.1002/ppul.23886</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7898-3006</orcidid></addata></record> |
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| ispartof | Pediatric pulmonology, 2017-12, Vol.52 (12), p.1592-1598 |
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| subjects | Alleles angiotensin‐converting enzyme Case-Control Studies Child Child, Preschool children community acquired pneumonia Community-Acquired Infections - blood Community-Acquired Infections - epidemiology Community-Acquired Infections - genetics Egypt - epidemiology Enzymes Female gene polymorphism Genetic Predisposition to Disease Genotype Humans Male Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - genetics Pneumonia - blood Pneumonia - epidemiology Pneumonia - genetics Polymerase Chain Reaction Polymorphism, Genetic Prospective Studies |
| title | Angiotensin‐converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case‐control study |
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