Immature platelet fraction (IPF) as a predictive value for thrombopoietic recovery after allogeneic stem cell transplantation

• Published in: International journal of hematology 2018-03, Vol.107 (3), p.320-326
• Main Authors: Sakuragi, Mikiko, Hayashi, Satoru, Maruyama, Miho, Kiyokawa, Tomoko, Nagamine, Keisuke, Fujita, Jiro, Maeda, Tetsuo, Kato, Hisashi, Kashiwagi, Hirokazu, Kanakura, Yuzuru, Tomiyama, Yoshiaki
• Format: Article
• Language: English
• Subjects: Allografts; Biomarkers - blood; Data recovery; Hematology; Hematopoietic Stem Cell Transplantation - adverse effects; Hematopoietic stem cells; Humans; Medicine; Medicine & Public Health; Oncology; Original Article; Pathogenesis; Patients; Platelet Count - methods; Platelet Function Tests - methods; Platelets; Predictions; Predictive Value of Tests; Recovery (Medical); Reproducibility of Results; Stem cell transplantation; Stem cells; Thrombocytopenia; Thrombocytopenia - blood; Thrombocytopenia - diagnosis; Thrombocytopenia - etiology; Thrombopoiesis - physiology; Transplantation
• ISSN: 0925-5710; 1865-3774
• DOI: 10.1007/s12185-017-2344-8

We consecutively examined the utility of measurements of percentage of immature platelet fraction (IPF%) and absolute IPF number (A-IPF) in predicting thrombopoietic recovery in 15 adult patients who underwent allogeneic hematopoietic stem cell transplantation (allo-SCT). Four patients were excluded from the evaluation due to insufficient data. Platelet count and IPF were measured by Sysmex XN-1000 (XN), a newer generation analyzer. First, we confirmed that platelet count measured by XN was more accurate than by XE-2100 (XE). IPF measurement was effective to predict the recovery in 7 of the 11 patients examined. Moreover, IPF measurement, especially IPF% measurement, suggested accelerated platelet turnover in two patients who failed to achieve platelet recovery by day 60. In addition to IPF%, A-IPF showed a complementary role on the prediction of thrombopoietic recovery. The increase in IPF% was only transient, while A-IPF values showed lasting increase during platelet recovery. In two patients (cases 6 and 7) an increase in A-IPF, but not in IPF%, was observed during platelet recovery. Our data suggest that IPF% and A-IPF measured by XN are useful for the prediction of thrombopoietic recovery and the assessment of pathogenesis of thrombocytopenia in patients after allo-SCT.