Maternal Residential Proximity to Waste Sites and Industrial Facilities and Oral Clefts in Offspring

Objective: This study examined the association between oral clefts and maternal residential proximity to waste sites or industries. Methods: In a case-control study, maternal residences at birth of 1781 births with oral clefts and 4368 comparison births were related to locations of waste sites and i...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2006-06, Vol.48 (6), p.565-572
Main Authors: Brender, Jean D., Zhan, F. Benjamin, Suarez, Lucina, Langlois, Peter H., Moody, Karen
Format: Article
Language:English
Subjects:
Birth defects
Case-Control Studies
Cleft Lip - epidemiology
Cleft Palate - epidemiology
Confidence Intervals
Environmental Exposure
Female
Geography
Hazardous Waste
Health risk assessment
Housing
Human exposure
Humans
Logistic Models
Maternal Exposure
Mothers
Mouth
Odds Ratio
ORIGINAL ARTICLES
Texas
Waste disposal
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Summary:Objective: This study examined the association between oral clefts and maternal residential proximity to waste sites or industries. Methods: In a case-control study, maternal residences at birth of 1781 births with oral clefts and 4368 comparison births were related to locations of waste sites and industrial facilities in Texas through geographic information systems. Results: Compared with women who lived farther, women who lived within a mile of these sites or facilities were not more likely to have offspring with oral clefts. Among women ≥ 35 years, oral clefts in offspring were associated with living within a mile of industrial facilities (odds ratio [OR] = 2.4, 95% confidence interval [CI] = 1.3-4.2), especially smelters (OR = 15.0, 95% CI = 2.8-151). Conclusion: These findings suggest that maternal residential proximity to industries might be associated with oral clefts in births to older mothers.
ISSN:1076-2752
1536-5948
DOI:10.1097/01.jom.0000214466.06076.07