Preparation and evaluation of two super(188)Re-radiopharmaceuticals for endovascular irradiation

Procedures for complexing DTPA with super(188)Re from a ready kit and by conventional manipulation were elaborated and the study of the stability and biodistribution of super(188)Re perrhenate and super(188)Re-DTPA were performed. Best labeling was achieved using DTPA (38 mM) with 2 mg/ml of SnCl su...

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Published in:Journal of radioanalytical and nuclear chemistry 2004-01, Vol.260 (2), p.363-368
Main Authors: Faintuch, B L, Faintuch, S, Muramoto, E
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description Procedures for complexing DTPA with super(188)Re from a ready kit and by conventional manipulation were elaborated and the study of the stability and biodistribution of super(188)Re perrhenate and super(188)Re-DTPA were performed. Best labeling was achieved using DTPA (38 mM) with 2 mg/ml of SnCl sub(2) super(.)2H sub(2)O. The radiochemical purity was 95.9 plus or minus 2.9%. The complex was stable for 24 hours when ascorbic acid was used. Greatest uptake of super(188)Re-DTPA was by kidneys (19.3 plus or minus 2.1%ID/g) and for super(188)Re-perrhenate by stomach (21.3 plus or minus 2.8%ID/g). In conclusion a kit of freeze-dried DTPA was developed. Organ damage is unlikely by virtue of its rapid urinary excretion.
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title Preparation and evaluation of two super(188)Re-radiopharmaceuticals for endovascular irradiation
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