Effect of Bariatric Surgery on Thyroid Function in Obese Patients: a Systematic Review and Meta-Analysis

We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if...

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Bibliographic Details
Published in:Obesity surgery 2017-12, Vol.27 (12), p.3292-3305
Main Authors: Guan, Bingsheng, Chen, YanYa, Yang, Jingge, Yang, Wah, Wang, Cunchuan
Format: Article
Language:English
Subjects:
Bariatric Surgery - adverse effects
Bariatric Surgery - statistics & numerical data
Gastrointestinal surgery
Humans
Hypothyroidism - epidemiology
Hypothyroidism - etiology
Medicine
Medicine & Public Health
Meta-analysis
Obesity
Obesity, Morbid - epidemiology
Obesity, Morbid - physiopathology
Obesity, Morbid - surgery
Postoperative Complications - blood
Postoperative Complications - epidemiology
Review Article
Surgery
Surgical outcomes
Systematic review
Thyroid Function Tests
Thyroid gland
Thyroid Gland - physiopathology
Thyroid Hormones - blood
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Summary:We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if necessary and feasible. As a result, 24 articles were included into meta-analysis. Bariatric surgery was associated with significant decrease in TSH, FT3, and T3 levels. However, FT4, T4, and rT3 levels were not significantly changed postoperatively. In addition, bariatric surgery had a favorable effect on overt and subclinical hypothyroid, with reduction of thyroid hormone requirements postoperatively. In conclusion, TSH, FT3, and T3 decrease are expected following bariatric surgery, as well as non-significant change of T4, FT4, and rT3 levels.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-017-2965-2