Reconnectable fiberscopes for chronic in vivo deep‐brain imaging

Reconnectable bundles consisting of thousands of optical fibers are shown to enable high‐quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of...

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Bibliographic Details
Published in:Journal of biophotonics 2018-04, Vol.11 (4), p.e201700106-n/a
Main Authors: Pochechuev, M. S., Fedotov, I. V., Ivashkina, O. I., Roshchina, M. A., Meshchankin, D.V., Sidorov‐Biryukov, D. A., Fedotov, A. B., Anokhin, K. V., Zheltikov, A. M.
Format: Article
Language:English
Subjects:
Brain
Calcium
Coding
Genetic code
Growth regulators
Image quality
Image transmission
Medical imaging
Neuroimaging
Neurology
Optical fibers
Rodents
Surgical implants
Transgenic mice
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Summary:Reconnectable bundles consisting of thousands of optical fibers are shown to enable high‐quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging. Experiments on various lines of transgenic mice verify the performance of this fiberscope as a powerful tool for chronic in vivo neuroimaging using genetically encoded calcium indicators, neuronal activity markers as well as axon growth regulators and brain‐specific protein drivers in deep regions of live brain. Reconnectable bundles consisting of thousands of optical fibers are shown to enable high‐quality image transmission, offering a platform for the creation of implantable fiberscopes for minimally invasive in vivo brain imaging.
ISSN:1864-063X
1864-0648
DOI:10.1002/jbio.201700106