Clinical Management of Cavernous Malformations

Purpose of Review This study aims to review the current epidemiology and clinical management of patients with cavernous malformations (CM). Recent Findings Hemorrhage is the most feared complication and leads to morbidity in patients with CM. Multiple studies including three meta-analyses have provi...

Full description

Saved in:
Bibliographic Details
Published in:Current cardiology reports 2017-12, Vol.19 (12), p.122-122, Article 122
Main Author: Flemming, Kelly D.
Format: Article
Language:English
Subjects:
Cardiology
Medicine
Medicine & Public Health
Section Editor
Stroke (JF Meschia
Topical Collection on Stroke
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Review This study aims to review the current epidemiology and clinical management of patients with cavernous malformations (CM). Recent Findings Hemorrhage is the most feared complication and leads to morbidity in patients with CM. Multiple studies including three meta-analyses have provided useful estimates of hemorrhage risk, but have failed to identify a modifiable risk factor for prevention of cavernous malformation related hemorrhage. In treating the CM itself, surgical risk is weighed against the natural history. However, accumulating knowledge regarding the roles of CCM 1 , 2 , and 3 genes has led to the discovery of potential therapeutic targets. Summary The risk of future hemorrhage in patients with CM is highest in those who have had previously clinical hemorrhages. Estimated risks are helpful in counseling patients and comparing to the risk of surgery. Future clinical trials of candidate medications are likely to target those patients with prior clinical hemorrhage in whom the surgical risk is deemed high.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-017-0931-1