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Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization
Abstract OBJECTIVES The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes f...
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| Published in: | European journal of cardio-thoracic surgery 2018-03, Vol.53 (3), p.603-609 |
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| container_end_page | 609 |
| container_issue | 3 |
| container_start_page | 603 |
| container_title | European journal of cardio-thoracic surgery |
| container_volume | 53 |
| creator | Zeriouh, Mohamed Sabashnikov, Anton Patil, Nikhil P Schmack, Bastian Zych, Barlomiej Mohite, Prashant N García Sáez, Diana Koch, Achim Mansur, Ashham Soresi, Simona Weymann, Alexander Marczin, Nandor Wahlers, Thorsten De Robertis, Fabio Simon, André Rüdiger Popov, Aron-Frederik |
| description | Abstract
OBJECTIVES
The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients.
METHODS
Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42). A detailed analysis of donor and recipient bacterial colonization status in treatment and control groups and their impact on outcome was performed.
RESULTS
The proportion of recipients colonized with Pseudomonas aeruginosa was lower in the taurolidine group at 3 months (P |
| doi_str_mv | 10.1093/ejcts/ezx359 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1953296917</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/ejcts/ezx359</oup_id><sourcerecordid>1953296917</sourcerecordid><originalsourceid>FETCH-LOGICAL-c361t-8115ea505e229a508592e0880ba28053227bbb6d5e85200a7f258a6903e25f703</originalsourceid><addsrcrecordid>eNp9kEtLxDAUhYMovneuJTtdWOcmaZpkKYMvENwouCtpmkqkbWqSgjO_3uioS1fnLr574HwInRC4JKDYwr6ZFBd2_cG42kL7RApWCFa-bOcbCBRClbCHDmJ8A4CKUbGL9qiCUpaC7SPzHC32HU56Dr53rRstdiPu5_EVp6DHOPV6TDo5P-LOB2xWMTmDO9cEH13EemyxGyZtEs5Ek9MGp3tsfO9Ht_5-PEI7ne6jPf7JQ_R8c_20vCseHm_vl1cPhWEVSYUkhFvNgVtKVU7JFbUgJTSaSuCMUtE0TdVyKzkF0KKjXOpKAbOUdwLYITrf9E7Bv882pnpw0dg-L7B-jjVRuURVioiMXmxQk2fEYLt6Cm7QYVUTqL-01t9a643WjJ_-NM_NYNs_-NdjBs42gJ-n_6s-AYdTgys</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1953296917</pqid></control><display><type>article</type><title>Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization</title><source>Oxford Journals Online</source><creator>Zeriouh, Mohamed ; Sabashnikov, Anton ; Patil, Nikhil P ; Schmack, Bastian ; Zych, Barlomiej ; Mohite, Prashant N ; García Sáez, Diana ; Koch, Achim ; Mansur, Ashham ; Soresi, Simona ; Weymann, Alexander ; Marczin, Nandor ; Wahlers, Thorsten ; De Robertis, Fabio ; Simon, André Rüdiger ; Popov, Aron-Frederik</creator><creatorcontrib>Zeriouh, Mohamed ; Sabashnikov, Anton ; Patil, Nikhil P ; Schmack, Bastian ; Zych, Barlomiej ; Mohite, Prashant N ; García Sáez, Diana ; Koch, Achim ; Mansur, Ashham ; Soresi, Simona ; Weymann, Alexander ; Marczin, Nandor ; Wahlers, Thorsten ; De Robertis, Fabio ; Simon, André Rüdiger ; Popov, Aron-Frederik</creatorcontrib><description>Abstract
OBJECTIVES
The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients.
METHODS
Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42). A detailed analysis of donor and recipient bacterial colonization status in treatment and control groups and their impact on outcome was performed.
RESULTS
The proportion of recipients colonized with Pseudomonas aeruginosa was lower in the taurolidine group at 3 months (P < 0.001) and at 1 year (P = 0.053) postoperatively, despite no differences before transplant (P = 1.000). Moreover, a complete eradication of Burkholderia cepacia and Stenotrophomonas maltophilias colonizations could be achieved in the taurolidine group, whereas in the non-taurolidine group, persistent B. cepacia and S. maltophilias colonizations were observed. Early outcome in the taurolidine group was superior regarding fraction of expired volume in 1 s at 3 and 6 months after surgery with 74.5 ± 14.6 vs 60.4 ± 17.5 (P < 0.001) and 80.6 ± 16.9 vs 67.2 ± 19.4 (P = 0.005) percent of predicted values, respectively. In terms of long-term overall survival (P = 0.277) and freedom from bronchiolitis obliterans syndrome (P = 0.979), both groups were comparable.
CONCLUSIONS
Taurolidine might be associated with a reduced proportion of CF patients colonized with multiresistant pathogens, particularly with P. aeruginosa. Long-term results should be further assessed in larger multicentre trials.</description><identifier>ISSN: 1010-7940</identifier><identifier>EISSN: 1873-734X</identifier><identifier>DOI: 10.1093/ejcts/ezx359</identifier><identifier>PMID: 29048473</identifier><language>eng</language><publisher>Germany: Oxford University Press</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Cystic Fibrosis - surgery ; Female ; Humans ; Lung Transplantation - methods ; Male ; Middle Aged ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - microbiology ; Retrospective Studies ; Taurine - analogs & derivatives ; Taurine - therapeutic use ; Thiadiazines - therapeutic use ; Treatment Outcome ; Young Adult</subject><ispartof>European journal of cardio-thoracic surgery, 2018-03, Vol.53 (3), p.603-609</ispartof><rights>The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. 2017</rights><rights>The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-8115ea505e229a508592e0880ba28053227bbb6d5e85200a7f258a6903e25f703</citedby><cites>FETCH-LOGICAL-c361t-8115ea505e229a508592e0880ba28053227bbb6d5e85200a7f258a6903e25f703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29048473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeriouh, Mohamed</creatorcontrib><creatorcontrib>Sabashnikov, Anton</creatorcontrib><creatorcontrib>Patil, Nikhil P</creatorcontrib><creatorcontrib>Schmack, Bastian</creatorcontrib><creatorcontrib>Zych, Barlomiej</creatorcontrib><creatorcontrib>Mohite, Prashant N</creatorcontrib><creatorcontrib>García Sáez, Diana</creatorcontrib><creatorcontrib>Koch, Achim</creatorcontrib><creatorcontrib>Mansur, Ashham</creatorcontrib><creatorcontrib>Soresi, Simona</creatorcontrib><creatorcontrib>Weymann, Alexander</creatorcontrib><creatorcontrib>Marczin, Nandor</creatorcontrib><creatorcontrib>Wahlers, Thorsten</creatorcontrib><creatorcontrib>De Robertis, Fabio</creatorcontrib><creatorcontrib>Simon, André Rüdiger</creatorcontrib><creatorcontrib>Popov, Aron-Frederik</creatorcontrib><title>Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization</title><title>European journal of cardio-thoracic surgery</title><addtitle>Eur J Cardiothorac Surg</addtitle><description>Abstract
OBJECTIVES
The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients.
METHODS
Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42). A detailed analysis of donor and recipient bacterial colonization status in treatment and control groups and their impact on outcome was performed.
RESULTS
The proportion of recipients colonized with Pseudomonas aeruginosa was lower in the taurolidine group at 3 months (P < 0.001) and at 1 year (P = 0.053) postoperatively, despite no differences before transplant (P = 1.000). Moreover, a complete eradication of Burkholderia cepacia and Stenotrophomonas maltophilias colonizations could be achieved in the taurolidine group, whereas in the non-taurolidine group, persistent B. cepacia and S. maltophilias colonizations were observed. Early outcome in the taurolidine group was superior regarding fraction of expired volume in 1 s at 3 and 6 months after surgery with 74.5 ± 14.6 vs 60.4 ± 17.5 (P < 0.001) and 80.6 ± 16.9 vs 67.2 ± 19.4 (P = 0.005) percent of predicted values, respectively. In terms of long-term overall survival (P = 0.277) and freedom from bronchiolitis obliterans syndrome (P = 0.979), both groups were comparable.
CONCLUSIONS
Taurolidine might be associated with a reduced proportion of CF patients colonized with multiresistant pathogens, particularly with P. aeruginosa. Long-term results should be further assessed in larger multicentre trials.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Cystic Fibrosis - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Lung Transplantation - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Retrospective Studies</subject><subject>Taurine - analogs & derivatives</subject><subject>Taurine - therapeutic use</subject><subject>Thiadiazines - therapeutic use</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>1010-7940</issn><issn>1873-734X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYMovneuJTtdWOcmaZpkKYMvENwouCtpmkqkbWqSgjO_3uioS1fnLr574HwInRC4JKDYwr6ZFBd2_cG42kL7RApWCFa-bOcbCBRClbCHDmJ8A4CKUbGL9qiCUpaC7SPzHC32HU56Dr53rRstdiPu5_EVp6DHOPV6TDo5P-LOB2xWMTmDO9cEH13EemyxGyZtEs5Ek9MGp3tsfO9Ht_5-PEI7ne6jPf7JQ_R8c_20vCseHm_vl1cPhWEVSYUkhFvNgVtKVU7JFbUgJTSaSuCMUtE0TdVyKzkF0KKjXOpKAbOUdwLYITrf9E7Bv882pnpw0dg-L7B-jjVRuURVioiMXmxQk2fEYLt6Cm7QYVUTqL-01t9a643WjJ_-NM_NYNs_-NdjBs42gJ-n_6s-AYdTgys</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Zeriouh, Mohamed</creator><creator>Sabashnikov, Anton</creator><creator>Patil, Nikhil P</creator><creator>Schmack, Bastian</creator><creator>Zych, Barlomiej</creator><creator>Mohite, Prashant N</creator><creator>García Sáez, Diana</creator><creator>Koch, Achim</creator><creator>Mansur, Ashham</creator><creator>Soresi, Simona</creator><creator>Weymann, Alexander</creator><creator>Marczin, Nandor</creator><creator>Wahlers, Thorsten</creator><creator>De Robertis, Fabio</creator><creator>Simon, André Rüdiger</creator><creator>Popov, Aron-Frederik</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180301</creationdate><title>Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization</title><author>Zeriouh, Mohamed ; Sabashnikov, Anton ; Patil, Nikhil P ; Schmack, Bastian ; Zych, Barlomiej ; Mohite, Prashant N ; García Sáez, Diana ; Koch, Achim ; Mansur, Ashham ; Soresi, Simona ; Weymann, Alexander ; Marczin, Nandor ; Wahlers, Thorsten ; De Robertis, Fabio ; Simon, André Rüdiger ; Popov, Aron-Frederik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c361t-8115ea505e229a508592e0880ba28053227bbb6d5e85200a7f258a6903e25f703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Cystic Fibrosis - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Lung Transplantation - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Retrospective Studies</topic><topic>Taurine - analogs & derivatives</topic><topic>Taurine - therapeutic use</topic><topic>Thiadiazines - therapeutic use</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeriouh, Mohamed</creatorcontrib><creatorcontrib>Sabashnikov, Anton</creatorcontrib><creatorcontrib>Patil, Nikhil P</creatorcontrib><creatorcontrib>Schmack, Bastian</creatorcontrib><creatorcontrib>Zych, Barlomiej</creatorcontrib><creatorcontrib>Mohite, Prashant N</creatorcontrib><creatorcontrib>García Sáez, Diana</creatorcontrib><creatorcontrib>Koch, Achim</creatorcontrib><creatorcontrib>Mansur, Ashham</creatorcontrib><creatorcontrib>Soresi, Simona</creatorcontrib><creatorcontrib>Weymann, Alexander</creatorcontrib><creatorcontrib>Marczin, Nandor</creatorcontrib><creatorcontrib>Wahlers, Thorsten</creatorcontrib><creatorcontrib>De Robertis, Fabio</creatorcontrib><creatorcontrib>Simon, André Rüdiger</creatorcontrib><creatorcontrib>Popov, Aron-Frederik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of cardio-thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeriouh, Mohamed</au><au>Sabashnikov, Anton</au><au>Patil, Nikhil P</au><au>Schmack, Bastian</au><au>Zych, Barlomiej</au><au>Mohite, Prashant N</au><au>García Sáez, Diana</au><au>Koch, Achim</au><au>Mansur, Ashham</au><au>Soresi, Simona</au><au>Weymann, Alexander</au><au>Marczin, Nandor</au><au>Wahlers, Thorsten</au><au>De Robertis, Fabio</au><au>Simon, André Rüdiger</au><au>Popov, Aron-Frederik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization</atitle><jtitle>European journal of cardio-thoracic surgery</jtitle><addtitle>Eur J Cardiothorac Surg</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>53</volume><issue>3</issue><spage>603</spage><epage>609</epage><pages>603-609</pages><issn>1010-7940</issn><eissn>1873-734X</eissn><abstract>Abstract
OBJECTIVES
The presence of bacterial colonization that causes chronic pulmonary infections in cystic fibrosis (CF) patients remains a key issue before lung transplantation. We sought to assess the impact of intraoperative taurolidine lavage on bacterial colonization and long-term outcomes following lung transplantation in CF patients.
METHODS
Between 2007 and 2013, 114 CF patients underwent lung transplantation at our institute, and taurolidine 2% bronchial lavage was applied in a substantial proportion of patients (n = 42). A detailed analysis of donor and recipient bacterial colonization status in treatment and control groups and their impact on outcome was performed.
RESULTS
The proportion of recipients colonized with Pseudomonas aeruginosa was lower in the taurolidine group at 3 months (P < 0.001) and at 1 year (P = 0.053) postoperatively, despite no differences before transplant (P = 1.000). Moreover, a complete eradication of Burkholderia cepacia and Stenotrophomonas maltophilias colonizations could be achieved in the taurolidine group, whereas in the non-taurolidine group, persistent B. cepacia and S. maltophilias colonizations were observed. Early outcome in the taurolidine group was superior regarding fraction of expired volume in 1 s at 3 and 6 months after surgery with 74.5 ± 14.6 vs 60.4 ± 17.5 (P < 0.001) and 80.6 ± 16.9 vs 67.2 ± 19.4 (P = 0.005) percent of predicted values, respectively. In terms of long-term overall survival (P = 0.277) and freedom from bronchiolitis obliterans syndrome (P = 0.979), both groups were comparable.
CONCLUSIONS
Taurolidine might be associated with a reduced proportion of CF patients colonized with multiresistant pathogens, particularly with P. aeruginosa. Long-term results should be further assessed in larger multicentre trials.</abstract><cop>Germany</cop><pub>Oxford University Press</pub><pmid>29048473</pmid><doi>10.1093/ejcts/ezx359</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford Journals Online |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Cystic Fibrosis - surgery Female Humans Lung Transplantation - methods Male Middle Aged Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology Retrospective Studies Taurine - analogs & derivatives Taurine - therapeutic use Thiadiazines - therapeutic use Treatment Outcome Young Adult |
| title | Use of taurolidine in lung transplantation for cystic fibrosis and impact on bacterial colonization |
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