Contribution of allelic variations to the phenotype of response to antidepressants and antipsychotics

Individualized medicine through molecular pharmacogenetics is one of the major future goals in clinical medicine. In psychopharmacology, pharmacogenetics became an expanding research component. Major research results were already attained: first, it is now feasible to predict a major proportion of t...

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Bibliographic Details
Published in:European archives of psychiatry and clinical neuroscience 2008-03, Vol.258 (Suppl 1), p.12-20
Main Authors: Maier, Wolfgang, Zobel, Astrid
Format: Article
Language:English
Subjects:
Alleles
Antidepressive Agents - pharmacokinetics
Antidepressive Agents - therapeutic use
Antipsychotic Agents - pharmacokinetics
Antipsychotic Agents - therapeutic use
Cytochrome P-450 CYP2D6 - genetics
Humans
Medicine
Medicine & Public Health
Mental Disorders - drug therapy
Mental Disorders - genetics
Mental Disorders - metabolism
Mental Disorders - psychology
Neurosciences
Phenotype
Psychiatry
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Summary:Individualized medicine through molecular pharmacogenetics is one of the major future goals in clinical medicine. In psychopharmacology, pharmacogenetics became an expanding research component. Major research results were already attained: first, it is now feasible to predict a major proportion of the interindividual variation of plasma levels of most antidepressants and antipsychotics by using the DNA-sequence variation in genes for crucial CYP P450-enzymes as CYP2D6. Second, it is now possible to relate serious side effects (tardive dyskinesia, weight gain) of antipsychotics to specific genetic variants of genes for target proteins. Third, a long list of mainly functional variants in target protein genes was explored for their predictive power for the beneficial and adverse treatment outcome. Although specific results transferable into clinical practice were not yet obtained in this respect, the proof of principle could be demonstrated.
ISSN:0940-1334
1433-8491
DOI:10.1007/s00406-007-1004-z