Successful chemotherapy with modified FOLFIRINOX for pancreatic acinar cell carcinoma

Abdominal ultrasonography revealed a pancreatic mass in a 67-year-old man with diabetes mellitus. Endoscopic ultrasound-guided fine needle aspiration led to the histological diagnosis of acinar cell carcinoma. The clinical stage was determined to be IVb based on findings of multiple metastatic lesio...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2017-12, Vol.10 (6), p.564-569
Main Authors: Hashimoto, Minami, Hikichi, Takuto, Suzuki, Tomohiro, Tai, Mayumi, Ichii, Osamu, Matsuhashi, Nobuo, Kita, Eisaku, Takahashi, Shintaro, Okubo, Yoshinori, Hakozaki, Hando, Ejiri, Yutaka, Ohira, Hiromasa
Format: Article
Language:English
Subjects:
Abdominal Surgery
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Case Report
Colorectal Surgery
Endoscopic Ultrasound-Guided Fine Needle Aspiration
Endosonography
Gastroenterology
Hepatology
Humans
Male
Medicine
Medicine & Public Health
Pancreatic Neoplasms
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - pathology
Surgical Oncology
Tomography, X-Ray Computed
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Summary:Abdominal ultrasonography revealed a pancreatic mass in a 67-year-old man with diabetes mellitus. Endoscopic ultrasound-guided fine needle aspiration led to the histological diagnosis of acinar cell carcinoma. The clinical stage was determined to be IVb based on findings of multiple metastatic lesions in the liver and lymph nodes, as well as splenic vein infiltration. Because the patient was not a surgical candidate, he underwent chemotherapy with modified FOLFIRINOX. In the absence of any severe adverse events, 12 courses of chemotherapy were delivered, resulting in marked shrinkage of both the primary and metastatic lesions. The outcome was judged to be a partial response, which was maintained even 9 months from the introduction of the chemotherapy. The results of this case suggest that modified FOLFIRINOX is safe and effective in the treatment of pancreatic acinar cell carcinoma.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-017-0785-5