Peptide-based fibrin-targeting probes for thrombus imaging

The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2017-10, Vol.46 (42), p.14488-1458
Main Authors: Oliveira, Bruno L, Caravan, Peter
Format: Article
Language:English
Subjects:
Animals
Fibrin - metabolism
Humans
Molecular Imaging - methods
Molecular Probes - chemistry
Molecular Probes - metabolism
Peptides - chemistry
Peptides - metabolism
Thrombosis - diagnostic imaging
Thrombosis - metabolism
Thrombosis - physiopathology
Thrombosis - therapy
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Summary:The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques. Emphasis is placed on work that our lab has explored over the last 15 years that has resulted in the progression of the fibrin-binding PET probe [ 64 Cu]FBP8 from preclinical studies into human trials. Herein we provide an overview of peptide-based fibrin-targeted probes developed for molecular imaging of thrombosis by different modalities with particular emphasis for nuclear imaging techniques.
ISSN:1477-9226
1477-9234
DOI:10.1039/c7dt02634j