Rotary and linear molecular motors driven by pulses of a chemical fuel

Many biomolecular motors catalyze the hydrolysis of chemical fuels, such as adenosine triphosphate, and use the energy released to direct motion through information ratchet mechanisms. Here we describe chemically-driven artificial rotary and linear molecular motors that operate through a fundamental...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2017-10, Vol.358 (6361), p.340-343
Main Authors: Erbas-Cakmak, Sundus, Fielden, Stephen D. P., Karaca, Ulvi, Leigh, David A., McTernan, Charlie T., Tetlow, Daniel J., Wilson, Miriam R.
Format: Article
Language:English
Subjects:
Acids
Adenosine triphosphate
ATP
Binding sites
Chemical fuels
Crown ethers
Energy consumption
Ethers
Fuels
Landing sites
Molecular motors
Oscillations
pH effects
Substrates
Trichloroacetic acid
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Summary:Many biomolecular motors catalyze the hydrolysis of chemical fuels, such as adenosine triphosphate, and use the energy released to direct motion through information ratchet mechanisms. Here we describe chemically-driven artificial rotary and linear molecular motors that operate through a fundamentally different type of mechanism. The directional rotation of [2]- and [3]catenane rotary molecular motors and the transport of substrates away from equilibrium by a linear molecular pump are induced by acid-base oscillations. The changes simultaneously switch the binding site affinities and the labilities of barriers on the track, creating an energy ratchet. The linear and rotary molecular motors are driven by aliquots of a chemical fuel, trichloroacetic acid. A single fuel pulse generates 360° unidirectional rotation of up to 87% of crown ethers in a [2]catenane rotary motor.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aao1377