Synthesis of pyrrolo[2,3- d]pyrimidine nucleoside derivatives as potential anti-HCV agents

A series of Toyocamycin analogues were examined as potential anti-HCV agents. Several Toyocamycin ( 4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio ( 18) and 5-carboxamide oxime derivatives ( 23 and 27) of Toyocamycin wer...

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Bibliographic Details
Published in:Bioorganic chemistry 2007-02, Vol.35 (1), p.25-34
Main Authors: Varaprasad, Chamakura V.N.S., Ramasamy, Kanda S., Girardet, Jean-Luc, Gunic, Esmir, Lai, Vicky, Zhong, Weidong, An, Haoyun, Hong, Zhi
Format: Article
Language:English
Subjects:
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
HCV NS5B inhibitors
Hepatitis C - drug therapy
Hepatitis C - metabolism
Hepatitis C - virology
Hepatitis C virus
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Pyrimidine Nucleosides - chemistry
Pyrimidines - chemistry
Pyrroles - chemistry
Pyrrolo[2,3- d]pyrimidine nucleosides
RNA-Dependent RNA Polymerase - antagonists & inhibitors
RNA-Dependent RNA Polymerase - metabolism
Toyocamycin
Toyocamycin - analogs & derivatives
Toyocamycin - chemical synthesis
Toyocamycin - pharmacology
Viral Nonstructural Proteins - antagonists & inhibitors
Viral Nonstructural Proteins - metabolism
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Summary:A series of Toyocamycin analogues were examined as potential anti-HCV agents. Several Toyocamycin ( 4) analogues were examined for their ability to inhibit HCV RNA in a replicon assay. Among the compounds examined 4-methylthio ( 18) and 5-carboxamide oxime derivatives ( 23 and 27) of Toyocamycin were found to have good activity and selectivity.
ISSN:0045-2068
1090-2120
DOI:10.1016/j.bioorg.2006.07.003