Group B Streptococcus Bacteremia Elicits β C Protein-Specific IgM and IgG in Humans

Group B Streptococcus (GBS) β C protein elicits protective antibodies in experimental animals, making β C protein an attractive component of a human GBS glycoconjugate vaccine. We determined whether natural exposure to β C protein elicits antibodies in humans. Geometric mean concentrations (in micro...

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Bibliographic Details
Published in:The Journal of infectious diseases 2007-02, Vol.195 (3), p.353-356
Main Authors: Pannaraj, Pia S., Kelly, Joanna K., Madoff, Lawrence C., Rench, Marcia A., Lachenauer, Catherine S., Edwards, Morven S., Baker, Carol J.
Format: Article
Language:English
Subjects:
Antibodies
Bacteremia
Bacteria
Bacterial diseases
Bacterial sepsis
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Human bacterial diseases
Infants
Infections
Infectious diseases
Medical sciences
Microbiology
Miscellaneous
Mothers
Neonatal diseases
Newborns
Streptococcus
Streptococcus agalactiae
Vaccination
Women
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Summary:Group B Streptococcus (GBS) β C protein elicits protective antibodies in experimental animals, making β C protein an attractive component of a human GBS glycoconjugate vaccine. We determined whether natural exposure to β C protein elicits antibodies in humans. Geometric mean concentrations (in micrograms per milliliter) of β C-specific immunoglobulin (Ig) M and IgG as determined by enzyme-linked immunosorbent assay were similar in serum from 16 colonized (0.82 and 0.76, respectively) and 48 age-matched noncolonized (0.96 and 0.74, respectively) pregnant women. Serum from 3 women with β C GBS bacteremia had significantly higher levels of IgM (6.0) and IgG (52.9) (P=.01 and 0.01, respectively). Invasive disease but not colonization elicits β C-specific IgM and IgG.
ISSN:0022-1899
1537-6613
DOI:10.1086/510627