Effects of photobiomodulation on experimental models of peripheral nerve injury

Phototherapy has demonstrated positive effects in the treatment of peripheral nerve injury, but there is a need to investigate the dosimetric parameters. Thus, the aim of the present study was to conduct a literature review on the effects of photobiomodulation with the use of low-level laser therapy...

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Bibliographic Details
Published in:Lasers in medical science 2017-12, Vol.32 (9), p.2155-2165
Main Authors: Andreo, L., Soldera, C. B., Ribeiro, B. G., de Matos, P. R. V., Bussadori, S. K., Fernandes, K. P. S., Mesquita-Ferrari, R. A.
Format: Article
Language:English
Subjects:
Clinical outcomes
Continuous radiation
Cytokines
Dentistry
Digital systems
Growth factors
Inflammation
Infrared radiation
Injuries
Lasers
Light therapy
Literature reviews
Mathematical models
Medical treatment
Medicine
Medicine & Public Health
Nervous system
Optical Devices
Optics
Photonics
Phototherapy
Quantum Optics
Recovery of function
Regeneration
Review Article
Standardization
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Summary:Phototherapy has demonstrated positive effects in the treatment of peripheral nerve injury, but there is a need to investigate the dosimetric parameters. Thus, the aim of the present study was to conduct a literature review on the effects of photobiomodulation with the use of low-level laser therapy (LLLT) on the treatment of peripheral nerve injury in experimental models. The databases of PubMed/MEDLINE, SCOPUS, and SPIE Digital Library were searched for articles on the use of LLLT in experimental models of peripheral nerve injury published in English between January 2007 and March 2016. The laser parameter variability was wavelength (632.8 to 980 nm), power (10 to 190 mW), and total energy (0.15 to 90 J) in pulsed or continuous wave and single or multiple points. Eighteen original articles demonstrating the effects of LLLT on the acceleration of functional recovery, morphological aspects as well as the modulation of the expression inflammatory cytokines, and growth factors were selected. LLLT is a viable phototherapeutic modality for the treatment of peripheral nerve injury, demonstrating positive effects on the neuromuscular repair process using either red or infrared light. The majority of studies used a power of up to 50 mW and total energy of up to 15 J administered to multiple points. The determination of these parameters is important to the standardization of a LLLT protocol to enhance the regeneration process following a peripheral nerve injury.
ISSN:0268-8921
1435-604X
DOI:10.1007/s10103-017-2359-7