Does smoking habit increase the micronuclei frequency in the oral mucosa of adults compared to non-smokers? A systematic review and meta-analysis

Objectives A systematic review of clinical studies to evaluate the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients was performed. Materials and methods A comprehensive search was carried out on MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO, and Coch...

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Bibliographic Details
Published in:Clinical oral investigations 2018-01, Vol.22 (1), p.81-91
Main Authors: de Geus, Juliana Larocca, Wambier, Letícia Maíra, Bortoluzzi, Marcelo Carlos, Loguercio, Alessandro D., Kossatz, Stella, Reis, Alessandra
Format: Article
Language:English
Subjects:
Clinical trials
Cytotoxicity
Dentistry
Dissertations & theses
Genotoxicity
Humans
Medicine
Meta-analysis
Micronuclei
Micronucleus Tests
Mouth Mucosa - cytology
Mouth Mucosa - pathology
Mucosa
Review
Smoking
Smoking - pathology
Studies
Systematic review
Tobacco
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Summary:Objectives A systematic review of clinical studies to evaluate the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients was performed. Materials and methods A comprehensive search was carried out on MEDLINE via PubMeb, Scopus, Web of Science, LILACS, BBO, and Cochrane Library and SIGLE without restrictions. Dissertations and thesis were searched using the ProQuest Dissertations and Periodicos Capes Thesis Databases. We included only cross-sectional clinical trials that compared the frequency of micronuclei in the oral mucosa of smokers and non-smokers in adult patients. Data After the removal of duplicates, 1338 articles were identified. After title and abstract screening, 35 studies remained. Eighteen studies were further excluded, whereas 17 studies remained for qualitative analysis and 16 for the meta-analysis of the primary and secondary outcomes. A significant difference in the frequency of micronuclei in smokers when compared to non-smokers was observed in the present study. Conclusions Despite the high variation in the methodology of the assessed studies, this study showed a higher frequency of micronuclei in exfoliated cells of smokers compared to non-smokers. Clinical significance The use of tobacco is associated with cytotoxic and genotoxic effects because a higher frequency of micronuclei in exfoliated cells of smokers was observed.
ISSN:1432-6981
1436-3771
DOI:10.1007/s00784-017-2246-4