Benzannulated Re(i)-NHC complexes: synthesis, photophysical properties and antimicrobial activity

A series of novel Re(i)(CO) -NHC complexes bearing unsubstituted benzimidazol-2-ylidene ligands as well as a variety of bisimine ligands has been prepared and comprehensively characterised. The complexes were found to exhibit potent antimicrobial activity on Gram-positive bacterial strains in the lo...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2017, Vol.46 (44), p.15269-15279
Main Authors: Siegmund, Daniel, Lorenz, Nicole, Gothe, Yvonne, Spies, Christian, Geissler, Bastian, Prochnow, Pascal, Nuernberger, Patrick, Bandow, Julia E, Metzler-Nolte, Nils
Format: Article
Language:English
Subjects:
Acetonitrile
Ambient temperature
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Coordination compounds
Ligands
Luminescence
Rhenium compounds
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Summary:A series of novel Re(i)(CO) -NHC complexes bearing unsubstituted benzimidazol-2-ylidene ligands as well as a variety of bisimine ligands has been prepared and comprehensively characterised. The complexes were found to exhibit potent antimicrobial activity on Gram-positive bacterial strains in the low micromolar concentration range, rendering these compounds interesting lead structures for the development of novel metal-based antibiotic agents. Further, the complexes exhibit pronounced luminescence with large Stokes shifts in acetonitrile and water at ambient temperature. The photophysical properties including luminescence lifetimes and quantum yields are consistent with emission from MLCT (d(Re) → π*(bisimine)) states.
ISSN:1477-9226
1477-9234
DOI:10.1039/c7dt02874a