Destination of aminoglycoside antibiotics in the ‘post-antibiotic era’

Aminoglycoside antibiotics (AGAs) were developed at the dawn of the antibiotics era and have significantly aided in the treatment of infectious diseases. Aminoglycosides have become one of the four major types of antibiotics in use today and, fortunately, still have an important role in the clinical...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 2018-01, Vol.71 (1), p.4-14
Main Authors: Takahashi, Yoshiaki, Igarashi, Masayuki
Format: Article
Language:English
Subjects:
631/154/309/2144
692/700/565/1436/2774
Aminoglycoside antibiotics
Aminoglycosides
Antibiotics
Antimicrobial agents
Bacteria
Bacterial diseases
Bacterial infections
Bacteriology
Biomedical and Life Sciences
Bioorganic Chemistry
Disease control
Drug resistance
Enzymes
Gonorrhea
Gram-negative bacteria
Gram-positive bacteria
Health services
Infectious diseases
Life Sciences
Medicinal Chemistry
Microbiology
Organic Chemistry
review-article
Salmonella
Side effects
Staphylococcus infections
Streptococcus infections
Tuberculosis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aminoglycoside antibiotics (AGAs) were developed at the dawn of the antibiotics era and have significantly aided in the treatment of infectious diseases. Aminoglycosides have become one of the four major types of antibiotics in use today and, fortunately, still have an important role in the clinical treatment of severe bacterial infections. In this review, the current usage, modes of action and side effects of AGAs, along with the most common bacterial resistance mechanisms, are outlined. Finally, the recent development situation and possibility of new AGAs in the ‘post-antibiotic era’ are considered.
ISSN:0021-8820
1881-1469
DOI:10.1038/ja.2017.117