Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception

A central tenet of cancer immunoediting is that T-cell recognition of tumor antigens drives the immunological elimination or shaping of a developing cancer. [...]the immune activation that eradicates recognized tumor cells also shapes tumor development and selects for mutations that may lead to an i...

Full description

Saved in:
Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2018-02, Vol.197 (3), p.278-280
Main Authors: Dubinett, Steven M, Spira, Avrum E
Format: Article
Language:English
Subjects:
Cancer therapies
Carcinoma, Non-Small-Cell Lung
Chemotherapy
Chronic obstructive pulmonary disease
Dendritic cells
Flow cytometry
Humans
Immunotherapy
Lung cancer
Lung Neoplasms
Lymphocytes
Mutation
Pulmonary Disease, Chronic Obstructive
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A central tenet of cancer immunoediting is that T-cell recognition of tumor antigens drives the immunological elimination or shaping of a developing cancer. [...]the immune activation that eradicates recognized tumor cells also shapes tumor development and selects for mutations that may lead to an immune-evasive cancer (5). In this issue of the Journal, Mark and colleagues (pp. 325-336) use a comprehensive flow cytometry panel to characterize the immune cell content in lung cancers and adjacent lung tissue from patients, with and without COPD, undergoing surgical resection (13). [...]in a retrospective cohort of patients with NSCLC treated with immune checkpoint inhibition, they demonstrated that the presence of COPD is associated with improved progression-free survival.
ISSN:1073-449X
1535-4970
DOI:10.1164/rccm.201710-2065ED