The relation between brain MRI findings and blood manganese levels in renal transplantation, hemodialysis, and peritoneal dialysis patients

Purpose Various factors can affect blood and tissue levels of trace elements in patients with end-stage renal disease. There are a few studies showing hyperintensity of basal ganglia associated with manganese deposition in hemodialysis (HD) patients. The present study aimed to investigate the intens...

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Bibliographic Details
Published in:International urology and nephrology 2018, Vol.50 (1), p.173-177
Main Authors: Akcan, Esra, Özkurt, Sultan, Sahin, Garip, Yalcin, Ahmet Ugur, Adapinar, Baki
Format: Article
Language:English
Subjects:
Basal ganglia
End-stage renal disease
Health risk assessment
Hemodialysis
Kidney diseases
Magnetic resonance imaging
Manganese
Medicine
Medicine & Public Health
Nephrology
Nephrology - Original Paper
Neuroimaging
Peritoneal dialysis
Peritoneum
Renal failure
Studies
Transplantation
Transplants & implants
Uremia
Urology
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Summary:Purpose Various factors can affect blood and tissue levels of trace elements in patients with end-stage renal disease. There are a few studies showing hyperintensity of basal ganglia associated with manganese deposition in hemodialysis (HD) patients. The present study aimed to investigate the intensity changes as markers of manganese deposition in the basal ganglia and to demonstrate their association with blood manganese levels using ICP/MS technique in HD, peritoneal dialysis (PD), and renal transplant patients. Methods The study included 20 HD, 20 PD, 20 renal transplant patients, and 20 healthy controls. Blood manganese levels were obtained, and cranial magnetic resonance images were evaluated for basal ganglia hyperintensity. Results Blood manganese levels were similar across all study groups ( p  = 0.308), whereas symmetric basal ganglia hyperintensity indicating manganese deposition was detected only in HD patients ( p  = 
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-017-1731-7