ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins

Abstract Summary ArachnoServer is a manually curated database that consolidates information on the sequence, structure, function and pharmacology of spider-venom toxins. Although spider venoms are complex chemical arsenals, the primary constituents are small disulfide-bridged peptides that target ne...

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Bibliographic Details
Published in:Bioinformatics 2018-03, Vol.34 (6), p.1074-1076
Main Authors: Pineda, Sandy S, Chaumeil, Pierre-Alain, Kunert, Anne, Kaas, Quentin, Thang, Mike W C, Le, Lien, Nuhn, Michael, Herzig, Volker, Saez, Natalie J, Cristofori-Armstrong, Ben, Anangi, Raveendra, Senff, Sebastian, Gorse, Dominique, King, Glenn F
Format: Article
Language:English
Subjects:
Animals
Automation, Laboratory
Disulfides - chemistry
Insect Proteins - chemistry
Peptides - chemistry
Spider Venoms - analysis
Spider Venoms - chemistry
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Summary:Abstract Summary ArachnoServer is a manually curated database that consolidates information on the sequence, structure, function and pharmacology of spider-venom toxins. Although spider venoms are complex chemical arsenals, the primary constituents are small disulfide-bridged peptides that target neuronal ion channels and receptors. Due to their high potency and selectivity, these peptides have been developed as pharmacological tools, bioinsecticides and drug leads. A new version of ArachnoServer (v3.0) has been developed that includes a bioinformatics pipeline for automated detection and analysis of peptide toxin transcripts in assembled venom-gland transcriptomes. ArachnoServer v3.0 was updated with the latest sequence, structure and functional data, the search-by-mass feature has been enhanced, and toxin cards provide additional information about each mature toxin. Availability and implementation http://arachnoserver.org Supplementary information Supplementary data are available at Bioinformatics online.
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btx661